DOI: 10.1128/jb.178.21.6369-6373.1996. Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP

Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP

10.1128/jb.178.21.6369-6373.1996

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

A mutation in the phoP/phoQ locus (pho-24) that results in unregulated expression of PhoP-activated genes (phenotype PhoP constitutive [PhoP(c)]) was mapped to phoQ. Change of a Thr to Ile at position 48 of PhoQ was responsible for the PhoP(c) phenotype (attenuation of mouse virulence, defects in epithelial cell invasion, and macrophage spacious phagosome formation). PhoP phosphorylation by membrane extracts required PhoQ, and PhoQ Ile-48-containing membranes demonstrated increased net phosphorylation of PhoP.

Bibliography

Gunn, J. S., Hohmann, E. L., & Miller, S. I. (1996). Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP. Journal of Bacteriology, 178(21), 6369â6373.

Authors 3

J S Gunn (first)
E L Hohmann (additional)
S I Miller (additional)

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Dates

Type	When
Created	8 years, 9 months ago (Nov. 10, 2016, 8:32 a.m.)
Deposited	4 years ago (July 29, 2021, 1:59 p.m.)
Indexed	1 year, 3 months ago (May 6, 2024, 12:37 p.m.)
Issued	28 years, 9 months ago (Nov. 1, 1996)
Published	28 years, 9 months ago (Nov. 1, 1996)
Published Print	28 years, 9 months ago (Nov. 1, 1996)

Funders 0

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BibTeX

@article{Gunn_1996, title={Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP}, volume={178}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.178.21.6369-6373.1996}, DOI={10.1128/jb.178.21.6369-6373.1996}, number={21}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Gunn, J S and Hohmann, E L and Miller, S I}, year={1996}, month=nov, pages={6369–6373} }

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