Guanine nucleotide-dependent assembly of FtsZ into filaments
10.1128/jb.176.9.2754-2758.1994
Crossref journal-article
American Society for Microbiology
Journal of Bacteriology (235)
Abstract

FtsZ is an essential cell division protein that is localized to the leading edge of the bacterial septum in a cytokinetic ring. It contains the tubulin signature motif and is a GTP binding protein with a GTPase activity. Further comparison of FtsZ with eukaryotic tubulins revealed some additional sequence similarities, perhaps indicating a similar GTP binding site. Examination of FtsZ incubated in vitro by electron microscopy revealed a guanine nucleotide-dependent assembly into protein filaments, supporting the hypothesis that the FtsZ ring is formed through self-assembly. FtsZ3, which is unable to bind GTP, does not polymerize, whereas FtsZ2, which binds GTP but is deficient in GTP hydrolysis, is capable of polymerization.

Bibliography

Mukherjee, A., & Lutkenhaus, J. (1994). Guanine nucleotide-dependent assembly of FtsZ into filaments. Journal of Bacteriology, 176(9), 2754–2758.

Authors 2
  1. A Mukherjee (first)
  2. J Lutkenhaus (additional)
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Dates
Type When
Created 8 years, 9 months ago (Nov. 7, 2016, 2:07 p.m.)
Deposited 4 years ago (July 29, 2021, 1:56 p.m.)
Indexed 2 weeks ago (Aug. 7, 2025, 4:40 p.m.)
Issued 31 years, 3 months ago (May 1, 1994)
Published 31 years, 3 months ago (May 1, 1994)
Published Print 31 years, 3 months ago (May 1, 1994)
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@article{Mukherjee_1994, title={Guanine nucleotide-dependent assembly of FtsZ into filaments}, volume={176}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.176.9.2754-2758.1994}, DOI={10.1128/jb.176.9.2754-2758.1994}, number={9}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Mukherjee, A and Lutkenhaus, J}, year={1994}, month=may, pages={2754–2758} }