Crossref journal-article
American Society for Microbiology
Journal of Bacteriology (235)
Abstract

The INO1 promoter of Saccharomyces cerevisiae includes a copy of an upstream repression sequence (URS1; 5'AGCCGCCGA 3') observed in the promoters of several unrelated yeast genes. Expression of INO1-lacZ and CYC1-lacI'Z, activated by the INO1 UASINO, is significantly decreased by the INO1 URS1.

Bibliography

Lopes, J. M., Schulze, K. L., Yates, J. W., Hirsch, J. P., & Henry, S. A. (1993). The INO1 promoter of Saccharomyces cerevisiae includes an upstream repressor sequence (URS1) common to a diverse set of yeast genes. Journal of Bacteriology, 175(13), 4235–4238.

Authors 5
  1. J M Lopes (first)
  2. K L Schulze (additional)
  3. J W Yates (additional)
  4. J P Hirsch (additional)
  5. S A Henry (additional)
References 25 Referenced 27
  1. Bailis , A. M. , J. M. Lopes , S. D. Kohlwein , and S. A. Henry . 1992 . Cis and trans regulatory elements required for regulation of the CHOJ gene of Saccharomyces cerevisiae . Nucleic Acids Res. 20 : 1411 - 1418 . (10.1093/nar/20.6.1411) / Nucleic Acids Res. / Cis and trans regulatory elements required for regulation of the CHOJ gene of Saccharomyces cerevisiae by Bailis A. M. (1992)
  2. Bailis , A. M. , M. A. Poole , G. M. Carman , and S. A. Henry . 1987 . The membrane-associated enzyme phosphatidylserine synthase is regulated at the level of mRNA abundance . Mol. Cell. Biol. 7 : 167 - 176 . / Mol. Cell. Biol. / The membrane-associated enzyme phosphatidylserine synthase is regulated at the level of mRNA abundance by Bailis A. M. (1987)
  3. Buckingham , L. E. , H. -T. Wang , R. T. Elder , R. M. McCarroll , M. R. Slater , and R. E. Esposito . 1990 . Nucleotide sequence and promoter analysis of SP013, a meiosis-specific gene of Saccharomyces cerevisiae . Proc. Natl. Acad. Sci. USA 87 : 9406 - 9410 . (10.1073/pnas.87.23.9406) / Proc. Natl. Acad. Sci. USA / Nucleotide sequence and promoter analysis of SP013, a meiosis-specific gene of Saccharomyces cerevisiae by Buckingham L. E. (1990)
  4. .Cooper T. Personal communication.
  5. Cooper , T. G. , D. Ferguson , R. Rai , and N. Bysani . 1990 . The GLN3 gene product is required for transcriptional activation of allantoin system gene expression in Saccharomyces cerevisiae . J. Bacteriol. 172 : 1014 - 1018 . (10.1128/jb.172.2.1014-1018.1990) / J. Bacteriol. / The GLN3 gene product is required for transcriptional activation of allantoin system gene expression in Saccharomyces cerevisiae by Cooper T. G. (1990)
  6. Culbertson , M. R. , T. F. Donahue , and S. A. Henry . 1976 . Control of inositol biosynthesis in Saccharomyces cerevisiae: properties of a repressible enzyme system in extracts of wildtype (Ino') cells . J. Bacteriol. 126 : 232 - 242 . (10.1128/jb.126.1.232-242.1976) / J. Bacteriol. / Control of inositol biosynthesis in Saccharomyces cerevisiae: properties of a repressible enzyme system in extracts of wildtype (Ino') cells by Culbertson M. R. (1976)
  7. Dean-Johnson , M. , and S. A. Henry . 1989 . Biosynthesis of inositol in yeast . J. Biol. Chem. 264 : 1274 - 1283 . (10.1016/S0021-9258(19)85082-2) / J. Biol. Chem. / Biosynthesis of inositol in yeast by Dean-Johnson M. (1989)
  8. Gaynor , P. M. , T. Gill , S. Toutenhoofd , E. F. Summers , P. McGraw , M. J. Homann , S. A. Henry , and G. M. Carman . 1993 . Regulation of phosphatidylethanolamine methyltransferase and phospholipid methyltransferase by phospholipid precursors in Saccharomyces cerevisiae . Biochim. Biophys. Acta. 1090 : 326 - 332 . (10.1016/0167-4781(91)90197-T) / Biochim. Biophys. Acta. / Regulation of phosphatidylethanolamine methyltransferase and phospholipid methyltransferase by phospholipid precursors in Saccharomyces cerevisiae by Gaynor P. M. (1993)
  9. Hirsch , J. P. , and S. A. Henry . 1986 . Expression of the Saccharomyces cerevisiae inosito1-1-phosphate synthase (INOJ) gene is regulated by factors that affect phospholipid synthesis . Mol. Cell. Biol. 6 : 3320 - 3328 . / Mol. Cell. Biol. / Expression of the Saccharomyces cerevisiae inosito1-1-phosphate synthase (INOJ) gene is regulated by factors that affect phospholipid synthesis by Hirsch J. P. (1986)
  10. Hoshizaki , D. K. , J. E. Hill , and S. A. Henry . 1990 . The S. cerevisiae IN04 gene encodes a small, highly basic protein required for derepression of phospholipid biosynthetic enzymes . J. Biol. Chem. 265 : 4736 - 4745 . (10.1016/S0021-9258(19)39624-3) / J. Biol. Chem. / The S. cerevisiae IN04 gene encodes a small, highly basic protein required for derepression of phospholipid biosynthetic enzymes by Hoshizaki D. K. (1990)
  11. .jackson J. and J. Lopes. Unpublished data.
  12. Kovari , L. , R. Sumrada , I. Kovari , and T. G. Cooper . 1990 . Multiple positive and negative cis-acting elements mediate induced arginase (CARl) gene expression in Saccharomyces cerevisiae . Mol. Cell. Biol. 10 : 5087 - 5097 . / Mol. Cell. Biol. / Multiple positive and negative cis-acting elements mediate induced arginase (CARl) gene expression in Saccharomyces cerevisiae by Kovari L. (1990)
  13. Lopes , J. M. , and S. A. Henry . 1991 . Interaction of trans and cis regulatory elements in the promoter of Saccharomyces cerevisiae . Nucleic Acids Res. 19 : 3987 - 3994 . (10.1093/nar/19.14.3987) / Nucleic Acids Res. / Interaction of trans and cis regulatory elements in the promoter of Saccharomyces cerevisiae by Lopes J. M. (1991)
  14. Lopes , J. M. , J. P. Hirsch , P. A. Chorgo , K. L. Schulze , and S. A. Henry . 1991 . Analysis of sequences involved in the INOI promoter that are involved in its regulation by phospholipid precursors . Nucleic Acids Res. 19 : 1687 - 1693 . (10.1093/nar/19.7.1687) / Nucleic Acids Res. / Analysis of sequences involved in the INOI promoter that are involved in its regulation by phospholipid precursors by Lopes J. M. (1991)
  15. Luche , R. M. , W. C. Smart , and T. G. Cooper . 1992 . Purification of the heteromeric protein binding to the URS1 transcriptional repression site in Saccharomyces cerevisiae . Proc. Natl. Acad. Sci. USA 89 : 7412 - 7416 . (10.1073/pnas.89.16.7412) / Proc. Natl. Acad. Sci. USA / Purification of the heteromeric protein binding to the URS1 transcriptional repression site in Saccharomyces cerevisiae by Luche R. M. (1992)
  16. Luche , R. M. , R. Sumrada , and T. G. Cooper . 1990 . A cis-acting element present in multiple genes serves as a repressor protein binding site for the yeast CARI gene . Mol. Cell. Biol. 10 : 3884 - 3895 . / Mol. Cell. Biol. / A cis-acting element present in multiple genes serves as a repressor protein binding site for the yeast CARI gene by Luche R. M. (1990)
  17. Myers , A. M. , A. Tzagoloff , D. M. Kinney , and C. J. Lusty . 1986 . Yeast shuttle vectors with multiple cloning sites suitable for construction of lacZ fusions . Gene 45 : 299 - 310 . (10.1016/0378-1119(86)90028-4) / Gene / Yeast shuttle vectors with multiple cloning sites suitable for construction of lacZ fusions by Myers A. M. (1986)
  18. Nikoloff , D. M. , P. McGraw , and S. A. Henry . 1992 . The INOI gene of Saccharomyces cerevisiae encodes a helix-loop-helix protein that is required for activation of phospholipid biosynthesis . Nucleic Acids Res. 20 : 3253 . (10.1093/nar/20.12.3253) / Nucleic Acids Res. / The INOI gene of Saccharomyces cerevisiae encodes a helix-loop-helix protein that is required for activation of phospholipid biosynthesis by Nikoloff D. M. (1992)
  19. Park , H. - D. , R. M. Luche , and T. G. Cooper . 1992 . The yeast UME6 gene product is required for transcriptional repression mediated by the CARl URS1 repressor binding site . Nucleic Acids Res. 20 : 1909 - 1915 . (10.1093/nar/20.8.1909) / Nucleic Acids Res. / The yeast UME6 gene product is required for transcriptional repression mediated by the CARl URS1 repressor binding site by Park H. (1992)
  20. Sternberg , P. W. , M. J. Stern , I. Clark , and I. Herskowitz . 1987 . Activation of the yeast HO gene by release from multiple negative controls . Cell 48 : 567 - 577 . (10.1016/0092-8674(87)90235-2) / Cell / Activation of the yeast HO gene by release from multiple negative controls by Sternberg P. W. (1987)
  21. Sumrada , R. A. , and T. G. Cooper . 1987 . Ubiquitous upstream repression sequences control activation of the inducible arginase gene in yeast . Proc. Natd. Acad. Sci. USA 84 : 3997 - 4001 . (10.1073/pnas.84.12.3997) / Proc. Natd. Acad. Sci. USA / Ubiquitous upstream repression sequences control activation of the inducible arginase gene in yeast by Sumrada R. A. (1987)
  22. Vershon , A. K. , N. M. Hollingsworth , and A. D. Johnson . 1992 . Meiotic induction of the yeast HOPI gene is controlled by positive and negative regulatory sites . Mol. Cell. Biol. 12 : 3706 - 3714 . / Mol. Cell. Biol. / Meiotic induction of the yeast HOPI gene is controlled by positive and negative regulatory sites by Vershon A. K. (1992)
  23. Wang , H. , and D. J. Stillman . 1990 . In vitro regulation of a SIN3-dependent DNA binding activity by stimulatory and inhibitory factors . Proc. Natl. Acad. Sci. USA 87 : 9761 - 9765 . (10.1073/pnas.87.24.9761) / Proc. Natl. Acad. Sci. USA / In vitro regulation of a SIN3-dependent DNA binding activity by stimulatory and inhibitory factors by Wang H. (1990)
  24. Wang , H. , and D. J. Stillman . 1993 . Transcriptional repression in Saccharomyces cerevisiae by a SIN3-lexA fusion protein . Mol. Cell. Biol. 13 : 1805 - 1814 . (10.1128/mcb.13.3.1805-1814.1993) / Mol. Cell. Biol. / Transcriptional repression in Saccharomyces cerevisiae by a SIN3-lexA fusion protein by Wang H. (1993)
  25. White , M. J. , J. P. Hirsch , and S. A. Henry . 1991 . The OP11 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper . J. Biol. Chem. 266 : 863 - 872 . (10.1016/S0021-9258(17)35253-5) / J. Biol. Chem. / The OP11 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper by White M. J. (1991)
Dates
Type When
Created 8 years, 9 months ago (Nov. 7, 2016, 3:03 p.m.)
Deposited 4 years, 1 month ago (July 29, 2021, 1:51 p.m.)
Indexed 1 month, 4 weeks ago (July 4, 2025, 9:13 p.m.)
Issued 32 years, 2 months ago (July 1, 1993)
Published 32 years, 2 months ago (July 1, 1993)
Published Print 32 years, 2 months ago (July 1, 1993)
Funders 0

None

@article{Lopes_1993, title={The INO1 promoter of Saccharomyces cerevisiae includes an upstream repressor sequence (URS1) common to a diverse set of yeast genes}, volume={175}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.175.13.4235-4238.1993}, DOI={10.1128/jb.175.13.4235-4238.1993}, number={13}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Lopes, J M and Schulze, K L and Yates, J W and Hirsch, J P and Henry, S A}, year={1993}, month=jul, pages={4235–4238} }