A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein
10.1128/jb.173.1.86-93.1991
Crossref journal-article
American Society for Microbiology
Journal of Bacteriology (235)
Abstract

The phoP-phoQ-regulated pagC locus is essential for full virulence and survival within macrophages of Salmonella typhimurium. The protein product, DNA sequence, and transcript of pagC were determined. The pagC locus encodes a single 188-amino-acid membrane protein that is similar to the ail-encoded eucaryotic cell invasion protein of Yersinia enterocolitica and the lom-encoded protein of bacteriophage lambda. The similarity of PagC and Ail to Lom leads us to hypothesize that Lom is a virulence protein and that bacteriophage gene transfer and lysogeny could have led to the development of proteins essential to survival within macrophages and eucaryotic cell invasion.

Bibliography

Pulkkinen, W. S., & Miller, S. I. (1991). A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein. Journal of Bacteriology, 173(1), 86–93.

Authors 2
  1. W S Pulkkinen (first)
  2. S I Miller (additional)
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Dates
Type When
Created 8 years, 9 months ago (Nov. 4, 2016, 5:07 p.m.)
Deposited 4 years, 1 month ago (July 29, 2021, 1:12 p.m.)
Indexed 1 month, 2 weeks ago (July 14, 2025, 11:32 p.m.)
Issued 34 years, 8 months ago (Jan. 1, 1991)
Published 34 years, 8 months ago (Jan. 1, 1991)
Published Print 34 years, 8 months ago (Jan. 1, 1991)
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@article{Pulkkinen_1991, title={A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein}, volume={173}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.173.1.86-93.1991}, DOI={10.1128/jb.173.1.86-93.1991}, number={1}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Pulkkinen, W S and Miller, S I}, year={1991}, month=jan, pages={86–93} }