DOI: 10.1128/jb.169.12.5579-5588.1987. Unique phenotype of opaque cells in the white-opaque transition of Candida albicans

Unique phenotype of opaque cells in the white-opaque transition of Candida albicans

10.1128/jb.169.12.5579-5588.1987

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

Select strains of Candida albicans switch reversibly and at extremely high frequency between a white and an opaque colony-forming phenotype, which has been referred to as the white-opaque transition. Cells in the white phase exhibit a cellular phenotype indistinguishable from that of most standard strains of C. albicans, but cells in the opaque phase exhibit an unusually large, elongate cellular shape. In comparing the white and opaque cellular phenotypes, the following findings are demonstrated. (i) The surface of the cell wall of maturing opaque cells when viewed by scanning electron microscopy exhibits a unique pimpled, or punctate, pattern not observed in white cells or standard strains of C. albicans. (ii) The dynamics of actin localization which accompanies opaque-cell growth first follows the pattern of budding cells during early opaque-bud growth and then the pattern of hypha-forming cells during late opaque-bud growth. (iii) A hypha-specific cell surface antigen is also expressed on the surface of opaque budding cells. (iv) An opaque-specific surface antigen is distributed in a punctate pattern.

Bibliography

Anderson, J. M., & Soll, D. R. (1987). Unique phenotype of opaque cells in the white-opaque transition of Candida albicans. Journal of Bacteriology, 169(12), 5579â5588.

Authors 2

J M Anderson (first)
D R Soll (additional)

References 27 Referenced 205

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Anderson , J. M. , and D. R. Soil . 1986 . Differences in actin localization during bud and hypha formation in the yeast Candida albicans . J. Gen. Microbiol. 132 : 2035 - 2047 . / J. Gen. Microbiol. / Differences in actin localization during bud and hypha formation in the yeast Candida albicans by Anderson J. M. (1986)
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Bedell , G. , A. Werth , and D. R. Soil . 1980 . The regulation of nuclear migration and division during synchronous bud formation in released stationary phase cultures of the yeast Candida albicans . Exp. Cell Res. 127 : 103 - 113 . (10.1016/0014-4827(80)90418-8) / Exp. Cell Res. / The regulation of nuclear migration and division during synchronous bud formation in released stationary phase cultures of the yeast Candida albicans by Bedell G. (1980)
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Slutsky , B. , M. Staebell , J. Anderson , L. Risen , M. Pfaller , and D. R. Soll . 1987 . " White-opaque transition ": a second highfrequency switching system in Candida J. Bacteriol. 169 : 189 - 197 . (10.1128/jb.169.1.189-197.1987) / J. Bacteriol. / White-opaque transition by Slutsky B. (1987)
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Soil , D. R. 1985 . The role of zinc in Candida dimorphism . Curr. Top. Med. Mycol. 1 : 258 - 285 . (10.1007/978-1-4613-9547-8_10) / Curr. Top. Med. Mycol. / The role of zinc in Candida dimorphism by Soil D. R. (1985)
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Soll , D. R. , and M. Herman . 1983 . Growth and the inducibility of mycelium formation in Candida albicans: a single cell analysis using a perfusion chamber . J. Gen. Microbiol. 129 : 2809 - 2824 . / J. Gen. Microbiol. / Growth and the inducibility of mycelium formation in Candida albicans: a single cell analysis using a perfusion chamber by Soll D. R. (1983)
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Dates

Type	When
Created	8 years, 9 months ago (Nov. 2, 2016, 6:32 p.m.)
Deposited	4 years ago (July 29, 2021, 1:33 p.m.)
Indexed	1 month ago (July 20, 2025, 12:13 a.m.)
Issued	37 years, 8 months ago (Dec. 1, 1987)
Published	37 years, 8 months ago (Dec. 1, 1987)
Published Print	37 years, 8 months ago (Dec. 1, 1987)

Funders 0

None

BibTeX

@article{Anderson_1987, title={Unique phenotype of opaque cells in the white-opaque transition of Candida albicans}, volume={169}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.169.12.5579-5588.1987}, DOI={10.1128/jb.169.12.5579-5588.1987}, number={12}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Anderson, J M and Soll, D R}, year={1987}, month=dec, pages={5579–5588} }

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