Relation of Chemotactic Response to the Amount of Receptor: Evidence for Different Efficiencies of Signal Transduction
10.1128/jb.138.3.739-747.1979
Crossref journal-article
American Society for Microbiology
Journal of Bacteriology (235)
Abstract

We determined the content of galactose-glucose-, maltose-, and ribose-binding proteins in cells of Escherichia coli K-12 grown in a variety of media and also measured the respective transport and chemotactic activities that depend on those binding proteins. Correlation of the level of induction of a particular binding protein with the extent of tactic activity mediated by that protein indicates that the magnitude of the tactic response to a particular stimulating compound is a direct function of the number of receptors per cell. In contrast, comparison of the magnitudes of response to substances recognized by independent receptors indicates that some stimulus-receptor complexes are more effective in eliciting tactic responses than are others. Thus, the magnitude of response to any particular stimulating compound is a function both of the number of receptors per cell and of the effectiveness of the stimulus-receptor complex. Considerations of available information about the tactic response to maltose suggest that the effectiveness of a stimulus-receptor complex is related to the transducer with which the receptor interacts. The tar product appears to be a relatively effective transducer of the signals it accepts from receptors for aspartate, α-methylaspartate, and maltose, whereas the trg product appears to be a relatively ineffective transducer of signals it accepts from receptors for galactose and ribose.

Bibliography

Koman, A., Harayama, S., & Hazelbauer, G. L. (1979). Relation of Chemotactic Response to the Amount of Receptor: Evidence for Different Efficiencies of Signal Transduction. Journal of Bacteriology, 138(3), 739–747.

Authors 3
  1. Ahmet Koman (first)
  2. Shigeaki Harayama (additional)
  3. Gerald L. Hazelbauer (additional)
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Dates
Type When
Created 5 years, 7 months ago (Jan. 3, 2020, 11:01 a.m.)
Deposited 4 years, 1 month ago (July 29, 2021, 1:32 p.m.)
Indexed 1 year, 10 months ago (Oct. 26, 2023, 4:43 a.m.)
Issued 46 years, 3 months ago (June 1, 1979)
Published 46 years, 3 months ago (June 1, 1979)
Published Print 46 years, 3 months ago (June 1, 1979)
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@article{Koman_1979, title={Relation of Chemotactic Response to the Amount of Receptor: Evidence for Different Efficiencies of Signal Transduction}, volume={138}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.138.3.739-747.1979}, DOI={10.1128/jb.138.3.739-747.1979}, number={3}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Koman, Ahmet and Harayama, Shigeaki and Hazelbauer, Gerald L.}, year={1979}, month=jun, pages={739–747} }