DOI: 10.1128/jb.123.1.154-161.1975. Genetic and kinetic evidence for different types of postreplication repair in Escherichia coli B

Genetic and kinetic evidence for different types of postreplication repair in Escherichia coli B

10.1128/jb.123.1.154-161.1975

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

The changes in molecular weight of deoxyribonucleic acid (DNA) synthesized after ultraviolte irradiation of Escherichia coli WP28 uvrA, and strains additionally mutant at polA, exrA, recA, and exrA and polA loci, were examined by alkaline sucrose gradient centrifugation. In a repari=deficient uvrA recA strain, the frequency of breaks in newly synthesized DNA was equal to that for pyrimidine dimers in parental DNA. Measurements of the amounts and rates of postreplication repair of these breaks indicate that (i) repair is two to three times faster when DNA polymerase I is present, although (ii) almost all breaks are repaired regardless of DNA polymerase I activity. (iii) Increased ultraviolet doses lead to an increase in the proportion of breaks remaining unrepaired in uvrA recA, UVRA exrA, and uvrA exrA polA strains. The numbers of unrepaired breaks resemble the numbers expected if repair of one lesion is prevented by proximity of a second lesion.

Bibliography

Sedgwick, S. G. (1975). Genetic and kinetic evidence for different types of postreplication repair in Escherichia coli B. Journal of Bacteriology, 123(1), 154â161.

Authors 1

S G Sedgwick (first)

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Dates

Type	When
Created	5 years, 8 months ago (Jan. 3, 2020, 10:46 a.m.)
Deposited	4 years, 1 month ago (July 29, 2021, 1:17 p.m.)
Indexed	1 year, 9 months ago (Nov. 16, 2023, 2:36 p.m.)
Issued	50 years, 2 months ago (July 1, 1975)
Published	50 years, 2 months ago (July 1, 1975)
Published Print	50 years, 2 months ago (July 1, 1975)

Funders 0

None

BibTeX

@article{Sedgwick_1975, title={Genetic and kinetic evidence for different types of postreplication repair in Escherichia coli B}, volume={123}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.123.1.154-161.1975}, DOI={10.1128/jb.123.1.154-161.1975}, number={1}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Sedgwick, S G}, year={1975}, month=jul, pages={154–161} }

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