Crossref journal-article
American Society for Microbiology
Journal of Bacteriology (235)
Abstract

A sequence of deoxyribonucleic acid of 2.7 times 10-6 to 3.3 times 10-6 daltons which includes the TEM beta-lactamase gene is present on the small plasmid RSF 1030 (R-Amp). This same sequence is present on plasmid derivatives that have received a translocation of deoxyribonucleic acid specifying the TEM beta-lactamase and is also present on naturally occurring plasmids of the F1, F11, N, X, O, I, C, and W incompatibility groups that do not specify ampicillin resistance or specify O-type beta-lactamases.

Bibliography

Heffron, F., Sublett, R., Hedges, R. W., Jacob, A., & Falkow, S. (1975). Origin of the TEM-beta-lactamase gene found on plasmids. Journal of Bacteriology, 122(1), 250–256.

Authors 5
  1. F Heffron (first)
  2. R Sublett (additional)
  3. R W Hedges (additional)
  4. A Jacob (additional)
  5. S Falkow (additional)
References 34 Referenced 186
  1. Brenner , D. J. , and S. Falkow . 1971 . Molecular relationships among members of the Enterobacteriaceae. Adv. Genet. 16 : 81 - 118 . (10.1016/S0065-2660(08)60355-7) / Enterobacteriaceae. Adv. Genet. / Molecular relationships among members of the by Brenner D. J. (1971)
  2. Brenner , D. J. , G. R. Fanning , K. E. Johnson , R. V. Citarella , and S. Falkow . 1969 . Polynucleotide sequence relationships among members of the Enterobacteriaceae . J. Bacteriol. 98 : 637 - 650 . (10.1128/jb.98.2.637-650.1969) / J. Bacteriol. / Polynucleotide sequence relationships among members of the Enterobacteriaceae by Brenner D. J. (1969)
  3. Chabbert , Y. A. , M. R. Scavizzi , T. L. Witchitz , G. R. Cerbaud , and D. H. Bouanchaud . 1972 . Incompatibility groups and the classification of fi- resistance factors . J. Bacteriol. 112 : 666 - 675 . (10.1128/jb.112.2.666-675.1972) / J. Bacteriol. / Incompatibility groups and the classification of fi- resistance factors by Chabbert Y. A. (1972)
  4. Chan , R. K. , D. Botstein , T. Watanabe , and Y. Ogata . 1972 . Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium . Virology 50 : 883 - 898 . (10.1016/0042-6822(72)90442-4) / Virology / Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium by Chan R. K. (1972)
  5. Clewell , D. B. , and D. R. Helinski . 1969 . Supercoiled circular DNA-protein complexes in Escherichia coli: purification and induced conversion to open circular DNA form . Proc. Natl. Acad. Sci. U.S.A. 62 : 1159 - 1166 . (10.1073/pnas.62.4.1159) / Proc. Natl. Acad. Sci. U.S.A. / Supercoiled circular DNA-protein complexes in Escherichia coli: purification and induced conversion to open circular DNA form by Clewell D. B. (1969)
  6. Clowes R. C. and W. Hayes. 1968. Experiments in microbial genetics Blackwell Scientific Publications Oxford.
  7. Coetzee , J. N. , N. Datta , and R. W. Hedges . 1972 . R factors from Proteus rettgeri . J. Gen. Microbiol. 72 : 543 - 552 . (10.1099/00221287-72-3-543) / J. Gen. Microbiol. / R factors from Proteus rettgeri by Coetzee J. N. (1972)
  8. Crosa , J. H. , D. J. Brenner , and S. Falkow . 1973 . Use of a single-strand-specific nuclease for analysis of bacterial and plasmid deoxyribonucleic acid homo- and heteroduplexes . J. Bacteriol. 115 : 904 - 911 . (10.1128/jb.115.3.904-911.1973) / J. Bacteriol. / Use of a single-strand-specific nuclease for analysis of bacterial and plasmid deoxyribonucleic acid homo- and heteroduplexes by Crosa J. H. (1973)
  9. Dale , J. W. , and J. T. Smith . 1974 . R factor-mediated ,B-lactamases that hydrolyze oxacillin: evidence for two distinct groups. J . Bacteriol. 119 : 351 - 356 . (10.1128/jb.119.2.351-356.1974) / Bacteriol. / R factor-mediated ,B-lactamases that hydrolyze oxacillin: evidence for two distinct groups. J by Dale J. W. (1974)
  10. Datta , N. , and R. W. Iledges . 1971 . Compatibility groups among fi- R factors . Nature (London) 234 : 222 - 223 . (10.1038/234222a0) / Nature (London) / Compatibility groups among fi- R factors by Datta N. (1971)
  11. Datta , N. , and R. W. Hedges . 1972 . Trimethoprim resistance conferred by W plasmids in Enterobacteriaceae . J. Gen. Microbiol. 72 : 349 - 355 . (10.1099/00221287-72-2-349) / J. Gen. Microbiol. / Trimethoprim resistance conferred by W plasmids in Enterobacteriaceae by Datta N. (1972)
  12. Datta , N. , and R. W. Hedges . 1973 . An I pilus-determining R-factor with anomalous compatibility properties, mobilizing a gentamicin-resistance plasmid . J. Gen. Microbiol. 77 : 11 - 17 . (10.1099/00221287-77-1-11) / J. Gen. Microbiol. / An I pilus-determining R-factor with anomalous compatibility properties, mobilizing a gentamicin-resistance plasmid by Datta N. (1973)
  13. Datta , N. , R. W. Hedges , E. J. Shaw , R. Sykes , and M. H. Richmond . 1971 . Properties of an R factor from Pseudomonas aeroginosa . J. Bacteriol. 108 : 1244 - 1249 . (10.1128/jb.108.3.1244-1249.1971) / J. Bacteriol. / Properties of an R factor from Pseudomonas aeroginosa by Datta N. (1971)
  14. Datta , N. , and P. Kontomichalou . 1965 . Penicillinase synthesis controlled by factors in Enterobacteriaceae . Nature (London) 208 : 239 - 241 . (10.1038/208239a0) / Nature (London) / Penicillinase synthesis controlled by factors in Enterobacteriaceae by Datta N. (1965)
  15. Davis R. W. M. Simon and N. Davidson. 1971. Electron microscope heteroduplex methods for mapping region of base sequence homology in nucleic acids p. 413-427. In L. Grossman and K. Moldave (ed.) Methods in enzymology vol. 21. Academic Press Inc. New York. (10.1016/S0076-6879(71)21033-8)
  16. Evans , J. , E. Galindo , J. Olarte , and S. Falkow . 1968 . , 6-Lactamases of R factors . J. Bacteriol. 96 : 1441 - 1442 . (10.1128/jb.96.4.1441-1442.1968) / J. Bacteriol. / 6-Lactamases of R factors by Evans J. (1968)
  17. Freifelder , D. R. , and D. Freifelder . 1968 . Studies on Escherichia coli sex factor. I. Specific labelling of F'lac DNA . J. Mol. Biol. 32 : 15 - 23 . (10.1016/0022-2836(68)90141-1) / J. Mol. Biol. / Studies on Escherichia coli sex factor. I. Specific labelling of F'lac DNA by Freifelder D. R. (1968)
  18. Hedges , R. W. , and N. Datta . 1972 . R factors conferring resistance to trimethoprim but not sulfonamides . J. Gen. Microbiol. 73 : 573 - 575 . (10.1099/00221287-73-3-573) / J. Gen. Microbiol. / R factors conferring resistance to trimethoprim but not sulfonamides by Hedges R. W. (1972)
  19. Hedges , R. W. , and N. Datta . 1973 . Plasmids determining I pili constitute a compatibility complex . J. Gen. Microbiol. 77 : 19 - 25 . (10.1099/00221287-77-1-19) / J. Gen. Microbiol. / Plasmids determining I pili constitute a compatibility complex by Hedges R. W. (1973)
  20. Hedges , R. W. , N. Datta , J. Coetzee , and S. Dennison . 1973 . R factors from Proteus morganii . J. Gen. Microbiol. 77 : 249 - 259 . (10.1099/00221287-77-2-249) / J. Gen. Microbiol. / R factors from Proteus morganii by Hedges R. W. (1973)
  21. Hedges , R. W. , N. Datta , P. Kontomichalou , and J. T. Smith . 1974 . Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility . J. Bacteriol. 117 : 56 - 62 (10.1128/jb.117.1.56-62.1974) / J. Bacteriol. / Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility by Hedges R. W. (1974)
  22. Hedges , R. W. , and A. Jacob . 1974 . Transposition of ampicillin resistance from RP4 to other replicons . Mol. Gen. Genet. 132 : 31 - 40 . (10.1007/BF00268228) / Mol. Gen. Genet. / Transposition of ampicillin resistance from RP4 to other replicons by Hedges R. W. (1974)
  23. Kontomichalou , P. , M. Mitani , and R. C. Clowes . 1970 . Circular R-factor molecular controlling penicillinase synthesis, replicating in Escherichia coli under relaxed or stringent control . J. Bacteriol. 104 : 34 - 44 . (10.1128/jb.104.1.34-44.1970) / J. Bacteriol. / Circular R-factor molecular controlling penicillinase synthesis, replicating in Escherichia coli under relaxed or stringent control by Kontomichalou P. (1970)
  24. Meynell , E. , and N. Datta . 1967 . Mutant drug resistance factors of high transmissibility . Nature (London) 214 : 885 - 887 . (10.1038/214885a0) / Nature (London) / Mutant drug resistance factors of high transmissibility by Meynell E. (1967)
  25. Richmond , M. H. , and R. B. Sykes . 1972 . The chromosomal integration of a fi-lactamase gene derived from the P-type of R factor RP1 in Escherichia coli . Genet. Res. 20 : 231 - 237 . (10.1017/S0016672300013732) / Genet. Res. / The chromosomal integration of a fi-lactamase gene derived from the P-type of R factor RP1 in Escherichia coli by Richmond M. H. (1972)
  26. Sharp , P. A. , S. N. Cohen , and N. Davidson . 1973 . Electron microscope heteroduplex studies of sequence relation among plasmids of Escherichia coli . J. Mol. Biol. 75 : 235 - 255 . (10.1016/0022-2836(73)90018-1) / J. Mol. Biol. / Electron microscope heteroduplex studies of sequence relation among plasmids of Escherichia coli by Sharp P. A. (1973)
  27. Smith , J. T. 1969 . R factor gene expression in gram-negative bacteria . J. Gen. Microbiol. 55 : 109 - 120 . (10.1099/00221287-55-1-109) / J. Gen. Microbiol. / R factor gene expression in gram-negative bacteria by Smith J. T. (1969)
  28. So , M. , J. H. Crosa , and S. Falkow . 1974 . Polynucleotide sequence relationships among Ent plasmids and the relationship between Ent and other plasmids . J. Bacteriol. 121 : 234 - 238 . (10.1128/jb.121.1.234-238.1975) / J. Bacteriol. / Polynucleotide sequence relationships among Ent plasmids and the relationship between Ent and other plasmids by So M. (1974)
  29. Starlinger , P. , and H. Saedler . 1972 . Insertion mutations in microorganisms . Biochimie 54 : 177 - 185 . (10.1016/S0300-9084(72)80102-0) / Biochimie / Insertion mutations in microorganisms by Starlinger P. (1972)
  30. Thomas C. A. Jr. 1966. Isolation of high molecular weight DNA from bacteria and cell nuclei p. 553-561. In C. L. Cantoni and D. R. Davis (ed.) Procedures in nucleic acid research. Harper and Row New York.
  31. Tye B.-K. R. K. Chan and D. Botstein. Packaging of an oversize transducing genome by Salmonella phage P22. J. Mol. Biol. 85:485-500. (10.1016/0022-2836(74)90311-8)
  32. Watanabe , T. , and T. Fukasawa . 1961 . Episomemediated transfer of drug resistance in Enterobacteriaceae. I. Transfer of resistance factors by conjugation . J. Bacteriol. 81 : 669 - 678 . (10.1128/jb.81.5.669-678.1961) / J. Bacteriol. / Episomemediated transfer of drug resistance in Enterobacteriaceae. I. Transfer of resistance factors by conjugation by Watanabe T. (1961)
  33. Watanabe , T. , C. Furuse , and S. Sakahumi . 1968 . Transduction of various R factors by phage P1 in Escherichia coli and by phage P22 in Salmonella typhimurium . J. Bacteriol. 96 : 1791 - 1795 . (10.1128/jb.96.5.1791-1795.1968) / J. Bacteriol. / Transduction of various R factors by phage P1 in Escherichia coli and by phage P22 in Salmonella typhimurium by Watanabe T. (1968)
  34. Watanabe , T. , H. Nishida , C. Ogata , T. Arai , and S. Sato . 1964 . Episome-mediated transfer of drug resistance in enterobacteriaceae. VII. Two types of naturally occurring R factors . J. Bacteriol. 88 : 716 - 726 . (10.1128/jb.88.3.716-726.1964) / J. Bacteriol. / Episome-mediated transfer of drug resistance in enterobacteriaceae. VII. Two types of naturally occurring R factors by Watanabe T. (1964)
Dates
Type When
Created 5 years, 8 months ago (Jan. 3, 2020, 10:08 a.m.)
Deposited 4 years, 1 month ago (July 29, 2021, 1:16 p.m.)
Indexed 3 months, 4 weeks ago (May 6, 2025, 2:31 p.m.)
Issued 50 years, 5 months ago (April 1, 1975)
Published 50 years, 5 months ago (April 1, 1975)
Published Print 50 years, 5 months ago (April 1, 1975)
Funders 0

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@article{Heffron_1975, title={Origin of the TEM-beta-lactamase gene found on plasmids}, volume={122}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.122.1.250-256.1975}, DOI={10.1128/jb.122.1.250-256.1975}, number={1}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Heffron, F and Sublett, R and Hedges, R W and Jacob, A and Falkow, S}, year={1975}, month=apr, pages={250–256} }