DOI: 10.1128/jb.106.3.966-971.1971. Effect of Serine Hydroxamate on the Growth of <i>Escherichia coli</i> [Penn]

Effect of Serine Hydroxamate on the Growth of Escherichia coli

10.1128/jb.106.3.966-971.1971

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

The structural analogue of l -serine, l -serine hydroxamate, inhibited the growth of Escherichia coli K-12. Of the other amino acid hydroxamates tested, only l -lysine hydroxamate reduced the rate of growth. Inhibition of growth by l -serine hydroxamate was rapidly reversed by the addition of l -serine to the bacterial culture or by removal of the analogue by filtration. The reversal of inhibition was specific for l -serine. l -Alanine, glycine, or adenine had no effect on an inhibited culture. No evidence for active transport of the analogue was obtained.

Bibliography

Tosa, T., & Pizer, L. I. (1971). Effect of Serine Hydroxamate on the Growth of Escherichia coli. Journal of Bacteriology, 106(3), 966â971.

Authors 2

Tetsuya Tosa (first)
Lewis I. Pizer (additional)

References 15 Referenced 53

Adelberg , E. A. 1958 . Selection of bacterial mutants which excrete antagonists of antimetabolites . J. Bacteriol. 76 : 326 . (10.1128/JB.76.3.326-326.1958) / J. Bacteriol. / Selection of bacterial mutants which excrete antagonists of antimetabolites by Adelberg E. A. (1958)
Britten , R. J. , and F. T. McClure . 1962 . The amino acid pool in Escherichia coli . Bacteriol. Rev. 26 : 292 - 335 . (10.1128/BR.26.3.292-335.1962) / Bacteriol. Rev. / The amino acid pool in Escherichia coli by Britten R. J. (1962)
Calvo , J. M. , M. Freundlich , and H. E. Umbarger . 1969 . Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants . J. Bacteriol. 97 : 1272 - 1282 . (10.1128/JB.97.3.1272-1282.1969) / J. Bacteriol. / Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants by Calvo J. M. (1969)
Pizer , L. 1. 1963 . The pathway and control of serine biosynthesis in Escherichia coli . J. Biol. Chem. 238 : 3934 - 3944 . (10.1016/S0021-9258(18)51809-3) / J. Biol. Chem. / The pathway and control of serine biosynthesis in Escherichia coli by Pizer L. (1963)
Pizer , L. I. , and M. L. Potochny . 1964 . Nutritional and regulatory aspects of serine metabolism in Escherichia coli . J. Bacteriol. 88 : 611 - 619 . (10.1128/JB.88.3.611-619.1964) / J. Bacteriol. / Nutritional and regulatory aspects of serine metabolism in Escherichia coli by Pizer L. I. (1964)
Roberts R. B. P. H. Abelson D. B. Cowie E. T. Bolton and R. J. Britten. 1955. Camegie Inst. Wash. PubI. 607.
Roper , J. A. , and H. Mcllwain . 1948 . Preparation and antibacterial action of some compounds structurally related to glutamic acid . Biochem. J. 42 : 485 . (10.1042/bj0420485) / Biochem. J. / Preparation and antibacterial action of some compounds structurally related to glutamic acid by Roper J. A. (1948)
Roth , J. R. , D. N. Anton , and P. E. Hartman . 1966 . Histidine regulatory mutants in Salmonella typhimurium . J. Mol. Biol. 22 : 305 - 323 . (10.1016/0022-2836(66)90134-3) / J. Mol. Biol. / Histidine regulatory mutants in Salmonella typhimurium by Roth J. R. (1966)
Schultz , S. C. , and A. K. Solomon . 1961 . Cation transport in E. coli. 1. Intracellular Na and K concentrations and net cation movement . J. Gen. Physiol. 45 : 355 - 369 . / J. Gen. Physiol. / Cation transport in E. coli. 1. Intracellular Na and K concentrations and net cation movement by Schultz S. C. (1961)
Sheppard , D. E. 1964 . Mutants of Salmonella typhimurium resistant to feedback inhibition by L-histidine . Genetics 50 : 611 - 623 . (10.1093/genetics/50.4.611) / Genetics / Mutants of Salmonella typhimurium resistant to feedback inhibition by L-histidine by Sheppard D. E. (1964)
Smith , H. S. , and L. 1. Pizer . 1968 . Abortive infection of Escherichia coli strain W by T2 bacteriophage . J. Mol. Biol. 37 : 131 - 149 . (10.1016/0022-2836(68)90078-8) / J. Mol. Biol. / Abortive infection of Escherichia coli strain W by T2 bacteriophage by Smith H. S. (1968)
Sugimoto , E. and L. I. Pizer . 1968 . The mechanism of end product inhibition of serine biosynthesis . J. Biol. Chem. 243 : 2081 - 2089 . (10.1016/S0021-9258(18)93450-2) / J. Biol. Chem. / The mechanism of end product inhibition of serine biosynthesis by Sugimoto E. (1968)
Tosa , T. , and L. 1. Pizer . 1971 . Biochemical bases for the antimetabolite action of L-serine hydroxamate . J. Bacteriol. 106 :000-000. (10.1128/jb.106.3.972-982.1971) / J. Bacteriol. / Biochemical bases for the antimetabolite action of L-serine hydroxamate by Tosa T. (1971)
Umbarger , H. E. , M. A. Umbarger , and P. M. L. Siu . 1963 . Biosynthesis of serine in Escherichia coli and Snlmonella typhimurium . J. Bacteriol. 85 : 1431 - 1439 . (10.1128/jb.85.6.1431-1439.1963) / J. Bacteriol. / Biosynthesis of serine in Escherichia coli and Snlmonella typhimurium by Umbarger H. E. (1963)
Zwaig , N. , W. S. Kistler , and E. C. C. Lin . 1970 . Glycerol kinase, the pacemaker for the dissimilation of glycerol in Escherichia coli . J. Bacteriol 102 : 753 - 759 . (10.1128/JB.102.3.753-759.1970) / J. Bacteriol / Glycerol kinase, the pacemaker for the dissimilation of glycerol in Escherichia coli by Zwaig N. (1970)

Dates

Type	When
Created	5 years, 7 months ago (Jan. 3, 2020, 9:31 a.m.)
Deposited	4 years, 3 months ago (May 27, 2021, 2:52 p.m.)
Indexed	1 month ago (July 25, 2025, 5:56 a.m.)
Issued	54 years, 2 months ago (June 1, 1971)
Published	54 years, 2 months ago (June 1, 1971)
Published Print	54 years, 2 months ago (June 1, 1971)

Funders 0

None

BibTeX

@article{Tosa_1971, title={Effect of Serine Hydroxamate on the Growth of Escherichia coli}, volume={106}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.106.3.966-971.1971}, DOI={10.1128/jb.106.3.966-971.1971}, number={3}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Tosa, Tetsuya and Pizer, Lewis I.}, year={1971}, month=jun, pages={966–971} }

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