DOI: 10.1128/iai.45.1.293-296.1984. Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A

Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A

10.1128/iai.45.1.293-296.1984

Crossref journal-article

American Society for Microbiology

Infection and Immunity (235)

Abstract

Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosamine-treated mice was almost comparable to that of natural lipid A. The pyrogenicity and Shwartzman induction activity of the synthetic analogs, however, were much less than those of natural lipid A.

Bibliography

Kotani, S., Takada, H., Tsujimoto, M., Ogawa, T., Harada, K., Mori, Y., Kawasaki, A., Tanaka, A., Nagao, S., & Tanaka, S. (1984). Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A. Infection and Immunity, 45(1), 293â296.

Authors 10

S Kotani (first)
H Takada (additional)
M Tsujimoto (additional)
T Ogawa (additional)
K Harada (additional)
Y Mori (additional)
A Kawasaki (additional)
A Tanaka (additional)
S Nagao (additional)
S Tanaka (additional)

References 0 Referenced 49

None

Dates

Type	When
Created	5 years, 8 months ago (Jan. 2, 2020, 10:04 p.m.)
Deposited	3 years, 6 months ago (March 4, 2022, 5:18 p.m.)
Indexed	1 year, 4 months ago (April 27, 2024, 7:50 a.m.)
Issued	41 years, 2 months ago (July 1, 1984)
Published	41 years, 2 months ago (July 1, 1984)
Published Print	41 years, 2 months ago (July 1, 1984)

Funders 0

None

BibTeX

@article{Kotani_1984, title={Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A}, volume={45}, ISSN={1098-5522}, url={http://dx.doi.org/10.1128/iai.45.1.293-296.1984}, DOI={10.1128/iai.45.1.293-296.1984}, number={1}, journal={Infection and Immunity}, publisher={American Society for Microbiology}, author={Kotani, S and Takada, H and Tsujimoto, M and Ogawa, T and Harada, K and Mori, Y and Kawasaki, A and Tanaka, A and Nagao, S and Tanaka, S}, year={1984}, month=jul, pages={293–296} }

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