DOI: 10.1128/iai.29.1.119-122.1980. Fatty acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic acid

Fatty acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic acid

10.1128/iai.29.1.119-122.1980

Crossref journal-article

American Society for Microbiology

Infection and Immunity (235)

Abstract

The ability of bovine serum albumin to inhibit the binding of group A streptococcal lipoteichoic acid (LTA) to human cells was investigated. Albumin blocked the ability of LTA to sensitize erythrocytes to agglutinate in the presence of anti-LTA in a dose-dependent manner. The inhibition of LTA binding to erythrocytes was demonstrated directly with radiolabeled LTA. At an albumin/LTA molar ratio of 1.5:1, albumin binding of the radiolabeled LTA at erythrocytes was inhibited by 45%. Analysis of the binding of radiolabeled LTA to erythrocytes in the presence of albumin indicated that albumin competitively inhibited the binding of LTA to putative cell membrane receptors, indicating that albumin and erythrocytes both bind to the same moiety on the LTA molecule.

Bibliography

Simpson, W. A., Ofek, I., & Beachey, E. H. (1980). Fatty acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic acid. Infection and Immunity, 29(1), 119â122.

Authors 3

W A Simpson (first)
I Ofek (additional)
E H Beachey (additional)

References 0 Referenced 32

None

Dates

Type	When
Created	5 years, 7 months ago (Jan. 2, 2020, 9:36 p.m.)
Deposited	3 years, 5 months ago (March 5, 2022, 8:28 a.m.)
Indexed	1 year, 10 months ago (Oct. 25, 2023, 3:24 a.m.)
Issued	45 years, 1 month ago (July 1, 1980)
Published	45 years, 1 month ago (July 1, 1980)
Published Print	45 years, 1 month ago (July 1, 1980)

Funders 0

None

BibTeX

@article{Simpson_1980, title={Fatty acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic acid}, volume={29}, ISSN={1098-5522}, url={http://dx.doi.org/10.1128/iai.29.1.119-122.1980}, DOI={10.1128/iai.29.1.119-122.1980}, number={1}, journal={Infection and Immunity}, publisher={American Society for Microbiology}, author={Simpson, W A and Ofek, I and Beachey, E H}, year={1980}, month=jul, pages={119–122} }

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