DOI: 10.1128/aem.62.5.1799-1802.1996. Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis

Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis

10.1128/aem.62.5.1799-1802.1996

Crossref journal-article

American Society for Microbiology

Applied and Environmental Microbiology (235)

Abstract

A new lanthionine-containing bacteriocin, variacin, displaying a broad host range of inhibition against gram-positive food spoilage bacteria, has been identified from two strains of Micrococcus varians isolated from meat fermentations. The new bacteriocin was purified, and its amino-terminal end and total amino acid composition were determined. The structural gene was isolated and analyzed. Variacin is resistant to heat and pH conditions from 2 to 10. Its primary sequence shows significant homology to lacticin 481 to Lactococcus lactis, which is more pronounced for the probacteriocin than for the leader sequence. Variacin, like lacticin 481, contains lanthionine and beta-methyllanthionine residues, but its leader sequence clearly resembles nonlantibiotic leader sequences. In particular, the prepeptide contains glycine residues at positions -1 and -2 of the processing site.

Bibliography

Pridmore, D., Rekhif, N., Pittet, A. C., Suri, B., & Mollet, B. (1996). Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis. Applied and Environmental Microbiology, 62(5), 1799â1802.

Authors 5

D Pridmore (first)
N Rekhif (additional)
A C Pittet (additional)
B Suri (additional)
B Mollet (additional)

References 0 Referenced 56

None

Dates

Type	When
Created	5 years, 7 months ago (Jan. 6, 2020, 1:17 p.m.)
Deposited	3 years, 6 months ago (Feb. 23, 2022, 12:33 p.m.)
Indexed	3 weeks, 3 days ago (Aug. 7, 2025, 5:01 p.m.)
Issued	29 years, 4 months ago (May 1, 1996)
Published	29 years, 4 months ago (May 1, 1996)
Published Print	29 years, 4 months ago (May 1, 1996)

Funders 0

None

BibTeX

@article{Pridmore_1996, title={Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis}, volume={62}, ISSN={1098-5336}, url={http://dx.doi.org/10.1128/aem.62.5.1799-1802.1996}, DOI={10.1128/aem.62.5.1799-1802.1996}, number={5}, journal={Applied and Environmental Microbiology}, publisher={American Society for Microbiology}, author={Pridmore, D and Rekhif, N and Pittet, A C and Suri, B and Mollet, B}, year={1996}, month=may, pages={1799–1802} }

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