Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
10.1128/mmbr.00040-05
Crossref journal-article
American Society for Microbiology
Microbiology and Molecular Biology Reviews (235)
Abstract

SUMMARYSince poly-ADP ribose was discovered over 40 years ago, there has been significant progress in research into the biology of mono- and poly-ADP-ribosylation reactions. During the last decade, it became clear that ADP-ribosylation reactions play important roles in a wide range of physiological and pathophysiological processes, including inter- and intracellular signaling, transcriptional regulation, DNA repair pathways and maintenance of genomic stability, telomere dynamics, cell differentiation and proliferation, and necrosis and apoptosis. ADP-ribosylation reactions are phylogenetically ancient and can be classified into four major groups: mono-ADP-ribosylation, poly-ADP-ribosylation, ADP-ribose cyclization, and formation ofO-acetyl-ADP-ribose. In the human genome, more than 30 different genes coding for enzymes associated with distinct ADP-ribosylation activities have been identified. This review highlights the recent advances in the rapidly growing field of nuclear mono-ADP-ribosylation and poly-ADP-ribosylation reactions and the distinct ADP-ribosylating enzyme families involved in these processes, including the proposed family of novel poly-ADP-ribose polymerase-like mono-ADP-ribose transferases and the potential mono-ADP-ribosylation activities of the sirtuin family of NAD+-dependent histone deacetylases. A special focus is placed on the known roles of distinct mono- and poly-ADP-ribosylation reactions in physiological processes, such as mitosis, cellular differentiation and proliferation, telomere dynamics, and aging, as well as “programmed necrosis” (i.e., high-mobility-group protein B1 release) and apoptosis (i.e., apoptosis-inducing factor shuttling). The proposed molecular mechanisms involved in these processes, such as signaling, chromatin modification (i.e., “histone code”), and remodeling of chromatin structure (i.e., DNA damage response, transcriptional regulation, and insulator function), are described. A potential cross talk between nuclear ADP-ribosylation processes and other NAD+-dependent pathways is discussed.

Bibliography

Hassa, P. O., Haenni, S. S., Elser, M., & Hottiger, M. O. (2006). Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going? Microbiology and Molecular Biology Reviews, 70(3), 789–829.

Authors 4
  1. Paul O. Hassa (first)
  2. Sandra S. Haenni (additional)
  3. Michael Elser (additional)
  4. Michael O. Hottiger (additional)
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Dates
Type When
Created 18 years, 11 months ago (Sept. 7, 2006, 3:08 p.m.)
Deposited 1 year, 6 months ago (Feb. 6, 2024, 5:16 a.m.)
Indexed 5 days, 16 hours ago (Aug. 20, 2025, 8:32 a.m.)
Issued 18 years, 11 months ago (Sept. 1, 2006)
Published 18 years, 11 months ago (Sept. 1, 2006)
Published Print 18 years, 11 months ago (Sept. 1, 2006)
Funders 0

None

@article{Hassa_2006, title={Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?}, volume={70}, ISSN={1098-5557}, url={http://dx.doi.org/10.1128/mmbr.00040-05}, DOI={10.1128/mmbr.00040-05}, number={3}, journal={Microbiology and Molecular Biology Reviews}, publisher={American Society for Microbiology}, author={Hassa, Paul O. and Haenni, Sandra S. and Elser, Michael and Hottiger, Michael O.}, year={2006}, month=sep, pages={789–829} }