DOI: 10.1128/mcb.8.2.843. DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog.

DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog.

10.1128/mcb.8.2.843

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

We report our molecular characterization of the Drosophila melanogaster Abelson gene (abl), a gene in which recessive loss-of-function mutations result in lethality at the pupal stage of development. This essential gene consists of 10 exons extending over 26 kilobase pairs of genomic DNA. The DNA sequence encodes a protein of 1,520 amino acids with strong sequence similarity to the human c-abl proto-oncogene beginning in the type lb 5' exon and extending through the region essential for tyrosine kinase activity. When the tyrosine kinase homologous region was expressed in Escherichia coli, phosphorylation of proteins on tyrosine residues was observed with an antiphosphotyrosine antibody. These results show that the abl gene is highly conserved through evolution and encodes a functional tyrosine protein kinase required for Drosophila development.

Bibliography

Henkemeyer, M. J., Bennett, R. L., Gertler, F. B., & Hoffmann, F. M. (1988). DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Molecular and Cellular Biology, 8(2), 843â853.

Authors 4

M J Henkemeyer (first)
R L Bennett (additional)
F B Gertler (additional)
F M Hoffmann (additional)

References 0 Referenced 41

None

Dates

Type	When
Created	9 years, 10 months ago (Sept. 30, 2015, 3:45 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 8:56 a.m.)
Indexed	1 year, 10 months ago (Oct. 24, 2023, 6:21 p.m.)
Issued	37 years, 6 months ago (Feb. 1, 1988)
Published	37 years, 6 months ago (Feb. 1, 1988)
Published Online	37 years, 6 months ago (Feb. 1, 1988)
Published Print	37 years, 6 months ago (Feb. 1, 1988)

Funders 0

None

BibTeX

@article{Henkemeyer_1988, title={DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog.}, volume={8}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.8.2.843}, DOI={10.1128/mcb.8.2.843}, number={2}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Henkemeyer, M J and Bennett, R L and Gertler, F B and Hoffmann, F M}, year={1988}, month=feb, pages={843–853} }

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