DOI: 10.1128/mcb.8.12.5570. Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

10.1128/mcb.8.12.5570

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

Compared with normal erbB-2 gp185, mutant erbB-2 proteins generated by mutations either in the transmembrane domain or by NH2-terminal deletion are able to transform NIH 3T3 cells at a 10- to 100-fold greater efficiency. Mutant proteins of both classes show increased tyrosine kinase activity, suggesting that an abnormal level of receptor-associated tyrosine kinase activity is a major determinant of erbB-2 oncogenic potential.

Bibliography

Segatto, O., King, C. R., Pierce, J. H., Di Fiore, P. P., & Aaronson, S. A. (1988). Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene. Molecular and Cellular Biology, 8(12), 5570â5574.

Authors 5

O Segatto (first)
C R King (additional)
J H Pierce (additional)
P P Di Fiore (additional)
S A Aaronson (additional)

References 0 Referenced 99

None

Dates

Type	When
Created	9 years, 10 months ago (Sept. 30, 2015, 3:49 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 8:56 a.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 12:29 a.m.)
Issued	36 years, 8 months ago (Dec. 1, 1988)
Published	36 years, 8 months ago (Dec. 1, 1988)
Published Online	36 years, 8 months ago (Dec. 1, 1988)
Published Print	36 years, 8 months ago (Dec. 1, 1988)

Funders 0

None

BibTeX

@article{Segatto_1988, title={Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.}, volume={8}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.8.12.5570}, DOI={10.1128/mcb.8.12.5570}, number={12}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Segatto, O and King, C R and Pierce, J H and Di Fiore, P P and Aaronson, S A}, year={1988}, month=dec, pages={5570–5574} }

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