Abstract
The murine influenza virus resistance locus Mx consists of more than one interferon-responsive transcription unit. We isolated clones of the transcripts of a second Mx gene (Mx2) which is closely linked to the well-characterized resistance gene and determined their sequences. Mx2 mRNA is more than 90% identical to Mx1 mRNA in the region corresponding to the amino termini of the encoded proteins. Mx2 mRNAs of mouse strains BALB/c and CBA have open reading frames apparently interrupted by mutations. Interferon-treated cells from strain A2G and other influenza virus-resistant strains failed to express detectable amounts of Mx2 transcripts.
Dates
Type | When |
---|---|
Created | 9 years, 11 months ago (Sept. 30, 2015, 3:48 p.m.) |
Deposited | 2 years, 8 months ago (Dec. 15, 2022, 8:54 a.m.) |
Indexed | 4 months, 3 weeks ago (April 10, 2025, 7:49 a.m.) |
Issued | 36 years, 11 months ago (Oct. 1, 1988) |
Published | 36 years, 11 months ago (Oct. 1, 1988) |
Published Online | 36 years, 11 months ago (Oct. 1, 1988) |
Published Print | 36 years, 11 months ago (Oct. 1, 1988) |
@article{Staeheli_1988, title={Identification of a second interferon-regulated murine Mx gene.}, volume={8}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.8.10.4524}, DOI={10.1128/mcb.8.10.4524}, number={10}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Staeheli, P and Sutcliffe, J G}, year={1988}, month=oct, pages={4524–4528} }