Abstract
We isolated a human gene (designated c-ros-1) homologous to the v-ros sequence of UR2 sarcoma virus. Ten exons, 1,414 base pairs spanning 26 kilobases, contained a tyrosine kinase domain, a transmembrane domain, and a part of an extracellular domain carrying an N glycosylation site which was not acquired by UR2 sarcoma virus. The predicted structure of c-ros-1 is unique among the src family and clearly distinct from the human insulin receptor.
Dates
Type | When |
---|---|
Created | 9 years, 10 months ago (Sept. 30, 2015, 3:37 p.m.) |
Deposited | 2 years, 8 months ago (Dec. 15, 2022, 8:54 a.m.) |
Indexed | 1 month, 1 week ago (July 14, 2025, 11:43 p.m.) |
Issued | 39 years ago (Aug. 1, 1986) |
Published | 39 years ago (Aug. 1, 1986) |
Published Online | 39 years ago (Aug. 1, 1986) |
Published Print | 39 years ago (Aug. 1, 1986) |
@article{Matsushime_1986, title={Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.}, volume={6}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.6.8.3000}, DOI={10.1128/mcb.6.8.3000}, number={8}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Matsushime, H and Wang, L H and Shibuya, M}, year={1986}, month=aug, pages={3000–3004} }