DOI: 10.1128/mcb.5.7.1694. Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.

Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.

10.1128/mcb.5.7.1694

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

The functional gene and three intronless pseudogenes for human triosephosphate isomerase were isolated from a recombinant DNA library and characterized in detail. The functional gene spans 3.5 kilobase pairs and is split into seven exons. Its promoter contains putative TATA and CCAAT boxes and is extremely rich in G and C residues (76%). The pseudogenes share a high degree of homology with the functional gene but contain mutations that preclude the synthesis of an active triosephosphate isomerase enzyme. Sequence divergence calculations indicate that these pseudogenes arose approximately 18 million years ago. We present evidence that there is a single functional gene in the human triosephosphate isomerase gene family.

Bibliography

Brown, J. R., Daar, I. O., Krug, J. R., & Maquat, L. E. (1985). Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Molecular and Cellular Biology, 5(7), 1694â1706.

Authors 4

J R Brown (first)
I O Daar (additional)
J R Krug (additional)
L E Maquat (additional)

References 0 Referenced 49

None

Dates

Type	When
Created	9 years, 11 months ago (Sept. 30, 2015, 3:33 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 8:51 a.m.)
Indexed	1 year, 6 months ago (Feb. 26, 2024, 9:51 p.m.)
Issued	40 years, 2 months ago (July 1, 1985)
Published	40 years, 2 months ago (July 1, 1985)
Published Online	40 years, 2 months ago (July 1, 1985)
Published Print	40 years, 2 months ago (July 1, 1985)

Funders 0

None

BibTeX

@article{Brown_1985, title={Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.}, volume={5}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.5.7.1694}, DOI={10.1128/mcb.5.7.1694}, number={7}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Brown, J R and Daar, I O and Krug, J R and Maquat, L E}, year={1985}, month=jul, pages={1694–1706} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        2,
        27
      ]
    ],
    "date-time": "2024-02-27T02:51:49Z",
    "timestamp": 1709002309276
  },
  "reference-count": 0,
  "publisher": "Informa UK Limited",
  "issue": "7",
  "content-domain": {
    "domain": [
      "asm.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1985,
        7
      ]
    ]
  },
  "abstract": "<jats:p>The functional gene and three intronless pseudogenes for human triosephosphate isomerase were isolated from a recombinant DNA library and characterized in detail. The functional gene spans 3.5 kilobase pairs and is split into seven exons. Its promoter contains putative TATA and CCAAT boxes and is extremely rich in G and C residues (76%). The pseudogenes share a high degree of homology with the functional gene but contain mutations that preclude the synthesis of an active triosephosphate isomerase enzyme. Sequence divergence calculations indicate that these pseudogenes arose approximately 18 million years ago. We present evidence that there is a single functional gene in the human triosephosphate isomerase gene family.</jats:p>",
  "DOI": "10.1128/mcb.5.7.1694",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2015,
        9,
        30
      ]
    ],
    "date-time": "2015-09-30T19:33:15Z",
    "timestamp": 1443641595000
  },
  "page": "1694-1706",
  "update-policy": "http://dx.doi.org/10.1128/asmj-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 49,
  "title": "Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.",
  "prefix": "10.1080",
  "volume": "5",
  "author": [
    {
      "given": "J R",
      "family": "Brown",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "I O",
      "family": "Daar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J R",
      "family": "Krug",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "L E",
      "family": "Maquat",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "301",
  "published-online": {
    "date-parts": [
      [
        1985,
        7,
        1
      ]
    ]
  },
  "container-title": "Molecular and Cellular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1128/MCB.5.7.1694",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        12,
        15
      ]
    ],
    "date-time": "2022-12-15T13:51:15Z",
    "timestamp": 1671112275000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://mcb.asm.org/lookup/doi/10.1128/MCB.5.7.1694"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1985,
        7
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "7",
    "published-online": {
      "date-parts": [
        [
          1985,
          7,
          1
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          1985,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1128/MCB.5.7.1694"
  ],
  "URL": "http://dx.doi.org/10.1128/MCB.5.7.1694",
  "relation": {},
  "ISSN": [
    "0270-7306",
    "1098-5549"
  ],
  "subject": [],
  "container-title-short": "Mol. Cell. Biol.",
  "published": {
    "date-parts": [
      [
        1985,
        7
      ]
    ]
  }
}