DOI: 10.1128/mcb.4.9.1929. Posttranscriptional modulation of gene expression in cultured rat hepatocytes.

Posttranscriptional modulation of gene expression in cultured rat hepatocytes.

10.1128/mcb.4.9.1929

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

The maintenance of high levels of two liver-specific mRNAs in cultured hepatocytes was achieved in a serum-free hormonally defined cell culture medium. However, this maintenance of liver-specific mRNA levels did not correlate with the level of transcription of the genes but was apparently due to increased stabilization of the tissue-specific mRNAs. The mRNA stabilization did not occur in serum-supplemented medium. In both defined and serum-supplemented medium, actin and tubulin mRNAs were also greatly increased, in both cases predominantly if not entirely due to increased mRNA stability.

Bibliography

Jefferson, D. M., Clayton, D. F., Darnell, J. E., & Reid, L. M. (1984). Posttranscriptional modulation of gene expression in cultured rat hepatocytes. Molecular and Cellular Biology, 4(9), 1929â1934.

Authors 4

D M Jefferson (first)
D F Clayton (additional)
J E Darnell (additional)
L M Reid (additional)

References 0 Referenced 87

None

Dates

Type	When
Created	9 years, 10 months ago (Sept. 29, 2015, 3:12 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 8:37 a.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 4:38 p.m.)
Issued	40 years, 11 months ago (Sept. 1, 1984)
Published	40 years, 11 months ago (Sept. 1, 1984)
Published Online	40 years, 11 months ago (Sept. 1, 1984)
Published Print	40 years, 11 months ago (Sept. 1, 1984)

Funders 0

None

BibTeX

@article{Jefferson_1984, title={Posttranscriptional modulation of gene expression in cultured rat hepatocytes.}, volume={4}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.4.9.1929}, DOI={10.1128/mcb.4.9.1929}, number={9}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Jefferson, D M and Clayton, D F and Darnell, J E and Reid, L M}, year={1984}, month=sep, pages={1929–1934} }

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