DOI: 10.1128/mcb.24.19.8778-8789.2004. Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes

Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes

10.1128/mcb.24.19.8778-8789.2004

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Bibliography

Ugi, S., Imamura, T., Maegawa, H., Egawa, K., Yoshizaki, T., Shi, K., Obata, T., Ebina, Y., Kashiwagi, A., & Olefsky, J. M. (2004). Protein Phosphatase 2A Negatively Regulates Insulinâs Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes. Molecular and Cellular Biology, 24(19), 8778â8789.

Authors 10

Satoshi Ugi (first)
Takeshi Imamura (additional)
Hiroshi Maegawa (additional)
Katsuya Egawa (additional)
Takeshi Yoshizaki (additional)
Kun Shi (additional)
Toshiyuki Obata (additional)
Yousuke Ebina (additional)
Atsunori Kashiwagi (additional)
Jerrold M. Olefsky (additional)

References 63 Referenced 191

10.1074/jbc.M003259200
10.1074/jbc.M101521200
10.1016/S0026-0495(97)90206-7
10.1016/0026-0495(95)90012-8
10.1016/S0960-9822(95)00059-5
10.1073/pnas.93.12.5699
10.1074/jbc.M306782200
10.1210/endo.141.11.7766
10.1074/jbc.272.4.2551
10.1016/S0026-0495(98)90193-7
10.1111/j.1432-1033.1996.0214q.x / Eur. J. Biochem. by Begum N. (1996)
10.1023/A:1006868409841
10.1016/S0960-9822(98)70444-0
10.1042/bj3350001
10.1038/378785a0
10.1074/jbc.274.12.8117
10.1074/jbc.M203132200
10.1074/jbc.M009489200
10.1073/pnas.93.19.10228
10.1073/pnas.94.18.9660
10.1074/jbc.M209459200
10.1074/jbc.275.6.4283
10.1016/S0014-5793(01)02242-6
10.1016/0092-8674(95)90405-0
10.1128/MCB.19.10.6765
10.1128/MCB.22.5.1352-1359.2002
10.1073/pnas.1332633100
10.1074/jbc.M302094200
10.1007/s00125-002-0974-7
10.1128/MCB.18.7.3708
10.1042/bj3440189 / Biochem. J. by Kobayashi T. (1999)
10.1074/jbc.271.49.31372
10.1128/MCB.18.12.6971
10.1126/science.281.5385.2042
10.1007/s001250100545 / Diabetologia by Levin K. (2001)
10.1074/jbc.M007281200 / J. Biol. Chem. by Liu Y. F. (2001)
10.1074/jbc.270.13.7724
10.1074/jbc.273.52.35339 / J. Biol. Chem. by Mateer S. C. (1998)
10.1016/S0968-0004(99)01375-4
10.1074/jbc.271.19.11222
10.1093/oxfordjournals.jbchem.a022009 / J. Biochem. (Tokyo) by Obata T. (1998)
10.1016/0092-8674(90)90726-U
10.1074/jbc.M105916200
10.1074/jbc.272.47.29911
10.1074/jbc.274.40.28816
10.1074/jbc.M007231200
10.1016/S0898-6568(01)00238-8 / Cell. Signal. by Resjo S. (2002)
10.1128/jvi.61.4.1240-1243.1987 / J. Virol. by Rundell K. (1987)
10.2337/diab.45.10.1379
10.1042/bj3330471
10.1210/en.2002-220517
10.1016/0092-8674(78)90303-3
10.1016/S0898-6568(00)00123-6
10.1016/0092-8674(93)90533-V
10.1093/emboj/16.18.5662
10.1016/S0021-9258(18)99905-9 / J. Biol. Chem. by Srinivasan M. (1994)
10.1074/jbc.274.20.14074
10.1074/jbc.272.48.30075
10.1074/jbc.273.9.5315
10.1128/MCB.22.7.2375-2387.2002
10.1074/jbc.M208904200
10.1128/MCB.19.6.4008
{'key': 'R63', 'first-page': '1988', 'volume': '11', 'author': 'Yang S. I.', 'year': '1991', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. by Yang S. I. (1991)

Dates

Type	When
Created	20 years, 11 months ago (Sept. 14, 2004, 3:58 p.m.)
Deposited	2 years, 4 months ago (March 27, 2023, 4:54 p.m.)
Indexed	1 month ago (July 24, 2025, 6:56 a.m.)
Issued	20 years, 10 months ago (Oct. 1, 2004)
Published	20 years, 10 months ago (Oct. 1, 2004)
Published Online	2 years, 4 months ago (March 27, 2023)
Published Print	20 years, 10 months ago (Oct. 1, 2004)

Funders 0

None

BibTeX

@article{Ugi_2004, title={Protein Phosphatase 2A Negatively Regulates Insulin’s Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes}, volume={24}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.24.19.8778-8789.2004}, DOI={10.1128/mcb.24.19.8778-8789.2004}, number={19}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Ugi, Satoshi and Imamura, Takeshi and Maegawa, Hiroshi and Egawa, Katsuya and Yoshizaki, Takeshi and Shi, Kun and Obata, Toshiyuki and Ebina, Yousuke and Kashiwagi, Atsunori and Olefsky, Jerrold M.}, year={2004}, month=oct, pages={8778–8789} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        24
      ]
    ],
    "date-time": "2025-07-24T10:56:12Z",
    "timestamp": 1753354572410
  },
  "reference-count": 63,
  "publisher": "Informa UK Limited",
  "issue": "19",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            10,
            1
          ]
        ],
        "date-time": "2004-10-01T00:00:00Z",
        "timestamp": 1096588800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://journals.asm.org/non-commercial-tdm-license"
    }
  ],
  "content-domain": {
    "domain": [
      "journals.asm.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        10,
        1
      ]
    ]
  },
  "DOI": "10.1128/mcb.24.19.8778-8789.2004",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        9,
        14
      ]
    ],
    "date-time": "2004-09-14T19:58:18Z",
    "timestamp": 1095191898000
  },
  "page": "8778-8789",
  "update-policy": "http://dx.doi.org/10.1128/asmj-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 191,
  "title": "Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes",
  "prefix": "10.1080",
  "volume": "24",
  "author": [
    {
      "given": "Satoshi",
      "family": "Ugi",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga"
        }
      ]
    },
    {
      "given": "Takeshi",
      "family": "Imamura",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, The Hillblom Diabetes Center, and The Whittier Diabetes Institute, La Jolla, California"
        }
      ]
    },
    {
      "given": "Hiroshi",
      "family": "Maegawa",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga"
        }
      ]
    },
    {
      "given": "Katsuya",
      "family": "Egawa",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga"
        }
      ]
    },
    {
      "given": "Takeshi",
      "family": "Yoshizaki",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga"
        }
      ]
    },
    {
      "given": "Kun",
      "family": "Shi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga"
        }
      ]
    },
    {
      "given": "Toshiyuki",
      "family": "Obata",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Molecular Genetics, Institutes for Enzyme Research, Graduate School of Medicine, University of Tokushima, Kuramoto, Tokushima, Japan"
        }
      ]
    },
    {
      "given": "Yousuke",
      "family": "Ebina",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Molecular Genetics, Institutes for Enzyme Research, Graduate School of Medicine, University of Tokushima, Kuramoto, Tokushima, Japan"
        }
      ]
    },
    {
      "given": "Atsunori",
      "family": "Kashiwagi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga"
        }
      ]
    },
    {
      "given": "Jerrold M.",
      "family": "Olefsky",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, The Hillblom Diabetes Center, and The Whittier Diabetes Institute, La Jolla, California"
        }
      ]
    }
  ],
  "member": "301",
  "published-online": {
    "date-parts": [
      [
        2023,
        3,
        27
      ]
    ]
  },
  "reference": [
    {
      "key": "R1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M003259200"
    },
    {
      "key": "R2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M101521200"
    },
    {
      "key": "R3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0026-0495(97)90206-7"
    },
    {
      "key": "R4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0026-0495(95)90012-8"
    },
    {
      "key": "R5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(95)00059-5"
    },
    {
      "key": "R6",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.12.5699"
    },
    {
      "key": "R7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M306782200"
    },
    {
      "key": "R8",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo.141.11.7766"
    },
    {
      "key": "R9",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.4.2551"
    },
    {
      "key": "R10",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0026-0495(98)90193-7"
    },
    {
      "key": "R11",
      "doi-asserted-by": "crossref",
      "first-page": "214",
      "DOI": "10.1111/j.1432-1033.1996.0214q.x",
      "volume": "238",
      "author": "Begum N.",
      "year": "1996",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "R12",
      "doi-asserted-by": "publisher",
      "DOI": "10.1023/A:1006868409841"
    },
    {
      "key": "R13",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(98)70444-0"
    },
    {
      "key": "R14",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj3350001"
    },
    {
      "key": "R15",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/378785a0"
    },
    {
      "key": "R16",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.12.8117"
    },
    {
      "key": "R17",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M203132200"
    },
    {
      "key": "R18",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M009489200"
    },
    {
      "key": "R19",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.19.10228"
    },
    {
      "key": "R20",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.18.9660"
    },
    {
      "key": "R21",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M209459200"
    },
    {
      "key": "R22",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.275.6.4283"
    },
    {
      "key": "R23",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0014-5793(01)02242-6"
    },
    {
      "key": "R24",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(95)90405-0"
    },
    {
      "key": "R25",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.19.10.6765"
    },
    {
      "key": "R26",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.22.5.1352-1359.2002"
    },
    {
      "key": "R27",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.1332633100"
    },
    {
      "key": "R28",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M302094200"
    },
    {
      "key": "R29",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s00125-002-0974-7"
    },
    {
      "key": "R30",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.18.7.3708"
    },
    {
      "key": "R31",
      "doi-asserted-by": "crossref",
      "first-page": "189",
      "DOI": "10.1042/bj3440189",
      "volume": "344",
      "author": "Kobayashi T.",
      "year": "1999",
      "journal-title": "Biochem. J."
    },
    {
      "key": "R32",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.49.31372"
    },
    {
      "key": "R33",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.18.12.6971"
    },
    {
      "key": "R34",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.281.5385.2042"
    },
    {
      "key": "R35",
      "doi-asserted-by": "crossref",
      "first-page": "824",
      "DOI": "10.1007/s001250100545",
      "volume": "44",
      "author": "Levin K.",
      "year": "2001",
      "journal-title": "Diabetologia"
    },
    {
      "key": "R36",
      "doi-asserted-by": "crossref",
      "first-page": "14459",
      "DOI": "10.1074/jbc.M007281200",
      "volume": "276",
      "author": "Liu Y. F.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "R37",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.13.7724"
    },
    {
      "key": "R38",
      "doi-asserted-by": "crossref",
      "first-page": "35339",
      "DOI": "10.1074/jbc.273.52.35339",
      "volume": "273",
      "author": "Mateer S. C.",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "R39",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0968-0004(99)01375-4"
    },
    {
      "key": "R40",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.19.11222"
    },
    {
      "key": "R41",
      "doi-asserted-by": "crossref",
      "first-page": "813",
      "DOI": "10.1093/oxfordjournals.jbchem.a022009",
      "volume": "123",
      "author": "Obata T.",
      "year": "1998",
      "journal-title": "J. Biochem. (Tokyo)"
    },
    {
      "key": "R42",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(90)90726-U"
    },
    {
      "key": "R43",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M105916200"
    },
    {
      "key": "R44",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.47.29911"
    },
    {
      "key": "R45",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.40.28816"
    },
    {
      "key": "R46",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M007231200"
    },
    {
      "key": "R47",
      "doi-asserted-by": "crossref",
      "first-page": "231",
      "DOI": "10.1016/S0898-6568(01)00238-8",
      "volume": "14",
      "author": "Resjo S.",
      "year": "2002",
      "journal-title": "Cell. Signal."
    },
    {
      "key": "R48",
      "doi-asserted-by": "crossref",
      "first-page": "1240",
      "DOI": "10.1128/jvi.61.4.1240-1243.1987",
      "volume": "61",
      "author": "Rundell K.",
      "year": "1987",
      "journal-title": "J. Virol."
    },
    {
      "key": "R49",
      "doi-asserted-by": "publisher",
      "DOI": "10.2337/diab.45.10.1379"
    },
    {
      "key": "R50",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj3330471"
    },
    {
      "key": "R51",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/en.2002-220517"
    },
    {
      "key": "R52",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(78)90303-3"
    },
    {
      "key": "R53",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0898-6568(00)00123-6"
    },
    {
      "key": "R54",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90533-V"
    },
    {
      "key": "R55",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/16.18.5662"
    },
    {
      "key": "R56",
      "doi-asserted-by": "crossref",
      "first-page": "12514",
      "DOI": "10.1016/S0021-9258(18)99905-9",
      "volume": "269",
      "author": "Srinivasan M.",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "R57",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.20.14074"
    },
    {
      "key": "R58",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.48.30075"
    },
    {
      "key": "R59",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.9.5315"
    },
    {
      "key": "R60",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.22.7.2375-2387.2002"
    },
    {
      "key": "R61",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M208904200"
    },
    {
      "key": "R62",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.19.6.4008"
    },
    {
      "key": "R63",
      "first-page": "1988",
      "volume": "11",
      "author": "Yang S. I.",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    }
  ],
  "container-title": "Molecular and Cellular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/MCB.24.19.8778-8789.2004",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://www.tandfonline.com/doi/pdf/10.1128/MCB.24.19.8778-8789.2004",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        3,
        27
      ]
    ],
    "date-time": "2023-03-27T20:54:57Z",
    "timestamp": 1679950497000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.tandfonline.com/doi/full/10.1128/MCB.24.19.8778-8789.2004"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        10,
        1
      ]
    ]
  },
  "references-count": 63,
  "journal-issue": {
    "issue": "19",
    "published-print": {
      "date-parts": [
        [
          2004,
          10,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1128/MCB.24.19.8778-8789.2004"
  ],
  "URL": "http://dx.doi.org/10.1128/MCB.24.19.8778-8789.2004",
  "relation": {},
  "ISSN": [
    "1098-5549"
  ],
  "subject": [],
  "container-title-short": "Molecular and Cellular Biology",
  "published": {
    "date-parts": [
      [
        2004,
        10,
        1
      ]
    ]
  },
  "assertion": [
    {
      "value": "2003-11-14",
      "order": 0,
      "name": "received",
      "label": "Received",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2004-06-22",
      "order": 1,
      "name": "accepted",
      "label": "Accepted",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2004-10-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}