DOI: 10.1128/mcb.16.8.4081. Profound Ligand-Independent Kinase Activation of Fibroblast Growth Factor Receptor 3 by the Activation Loop Mutation Responsible for a Lethal Skeletal Dysplasia, Thanatophoric Dysplasia Type II

Profound Ligand-Independent Kinase Activation of Fibroblast Growth Factor Receptor 3 by the Activation Loop Mutation Responsible for a Lethal Skeletal Dysplasia, Thanatophoric Dysplasia Type II

10.1128/mcb.16.8.4081

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Bibliography

Webster, M. K., dâAvis, P. Y., Robertson, S. C., & Donoghue, D. J. (1996). Profound Ligand-Independent Kinase Activation of Fibroblast Growth Factor Receptor 3 by the Activation Loop Mutation Responsible for a Lethal Skeletal Dysplasia, Thanatophoric Dysplasia Type II. Molecular and Cellular Biology, 16(8), 4081â4087.

Authors 4

Melanie K. Webster (first)
Patricia Y. d’Avis (additional)
Scott C. Robertson (additional)
Daniel J. Donoghue (additional)

References 35 Referenced 141

10.1136/jmg.26.1.37
10.1016/0092-8674(86)90779-8
{'key': 'CIT0003', 'first-page': '368', 'volume': '56', 'author': 'Bellus G. A.', 'year': '1995', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. by Bellus G. A. (1995)
10.1038/ng0795-357
10.1128/MCB.7.8.2745
10.1091/mbc.6.12.1861
10.1016/0092-8674(86)90786-5
Galvin, B. D., K. C. Hart, A. N. Meyer, M. K. Webster, and D. J. Donoghue. Constitutive receptor activation by Crouzon syndrome mutations in FGFR2 and FGFR2/Neu chimeras. Proc. Natl. Acad. Sci. USA, in press.
10.1016/0006-291X(92)90812-Y
10.1016/0076-6879(91)00126-H
10.1038/372746a0
10.1016/0167-4889(92)90136-Y
10.1016/S0065-230X(08)60821-0
10.1073/pnas.88.4.1095
{'key': 'CIT0015', 'first-page': '2229', 'volume': '6', 'author': 'Keegan K.', 'year': '1991', 'journal-title': 'Oncogene'} / Oncogene by Keegan K. (1991)
10.1182/blood.V85.3.790.bloodjournal853790
10.1002/ajmg.1320330420 / Am. J. Med. Genet. by MacDonald I. M. (1989)
10.1128/MCB.16.3.977
10.1038/358681a0
10.1016/S0168-9525(00)89088-5
10.1073/pnas.92.23.10560
10.1074/jbc.270.44.26037
10.1136/jmg.23.4.328
10.1006/dbio.1993.1040
{'key': 'CIT0025', 'first-page': '1', 'volume': '10', 'author': 'Rimoin D. L.', 'year': '1974', 'journal-title': 'Birth Defects Original Article Series'} / Birth Defects Original Article Series by Rimoin D. L. (1974)
10.1038/371252a0
10.1038/ng0595-11
10.1126/science.7824936
10.1136/jmg.10.3.243 / J. Med. Genet. by Shah K. (1973)
10.1016/0092-8674(94)90302-6
10.1093/hmg/4.11.2175
10.1038/ng0395-321
10.1002/j.1460-2075.1996.tb00384.x
10.1083/jcb.123.3.549 / J. Cell Biol. by Xu Y. F. (1993)
10.1016/S0021-9258(17)35272-9

Dates

Type	When
Created	9 years, 10 months ago (Oct. 8, 2015, 8:25 p.m.)
Deposited	2 years, 5 months ago (March 29, 2023, 2:15 p.m.)
Indexed	2 months ago (June 26, 2025, 2:26 p.m.)
Issued	29 years ago (Aug. 1, 1996)
Published	29 years ago (Aug. 1, 1996)
Published Online	2 years, 5 months ago (March 29, 2023)
Published Print	29 years ago (Aug. 1, 1996)

Funders 0

None

BibTeX

@article{Webster_1996, title={Profound Ligand-Independent Kinase Activation of Fibroblast Growth Factor Receptor 3 by the Activation Loop Mutation Responsible for a Lethal Skeletal Dysplasia, Thanatophoric Dysplasia Type II}, volume={16}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.16.8.4081}, DOI={10.1128/mcb.16.8.4081}, number={8}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Webster, Melanie K. and d’Avis, Patricia Y. and Robertson, Scott C. and Donoghue, Daniel J.}, year={1996}, month=aug, pages={4081–4087} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        26
      ]
    ],
    "date-time": "2025-06-26T18:26:00Z",
    "timestamp": 1750962360771
  },
  "reference-count": 35,
  "publisher": "Informa UK Limited",
  "issue": "8",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1996,
            8,
            1
          ]
        ],
        "date-time": "1996-08-01T00:00:00Z",
        "timestamp": 838857600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://journals.asm.org/non-commercial-tdm-license"
    }
  ],
  "content-domain": {
    "domain": [
      "journals.asm.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        8,
        1
      ]
    ]
  },
  "DOI": "10.1128/mcb.16.8.4081",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2015,
        10,
        9
      ]
    ],
    "date-time": "2015-10-09T00:25:15Z",
    "timestamp": 1444350315000
  },
  "page": "4081-4087",
  "update-policy": "http://dx.doi.org/10.1128/asmj-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 141,
  "title": "Profound Ligand-Independent Kinase Activation of Fibroblast Growth Factor Receptor 3 by the Activation Loop Mutation Responsible for a Lethal Skeletal Dysplasia, Thanatophoric Dysplasia Type II",
  "prefix": "10.1080",
  "volume": "16",
  "author": [
    {
      "given": "Melanie K.",
      "family": "Webster",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093-0367"
        }
      ]
    },
    {
      "given": "Patricia Y.",
      "family": "d\u2019Avis",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093-0367"
        }
      ]
    },
    {
      "given": "Scott C.",
      "family": "Robertson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093-0367"
        }
      ]
    },
    {
      "given": "Daniel J.",
      "family": "Donoghue",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093-0367"
        }
      ]
    }
  ],
  "member": "301",
  "published-online": {
    "date-parts": [
      [
        2023,
        3,
        29
      ]
    ]
  },
  "reference": [
    {
      "key": "CIT0001",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jmg.26.1.37"
    },
    {
      "key": "CIT0002",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(86)90779-8"
    },
    {
      "key": "CIT0003",
      "first-page": "368",
      "volume": "56",
      "author": "Bellus G. A.",
      "year": "1995",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "CIT0004",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/ng0795-357"
    },
    {
      "key": "CIT0005",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.7.8.2745"
    },
    {
      "key": "CIT0006",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.6.12.1861"
    },
    {
      "key": "CIT0007",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(86)90786-5"
    },
    {
      "key": "CIT0008",
      "unstructured": "Galvin, B. D., K. C. Hart, A. N. Meyer, M. K. Webster, and D. J. Donoghue. Constitutive receptor activation by Crouzon syndrome mutations in FGFR2 and FGFR2/Neu chimeras. Proc. Natl. Acad. Sci. USA, in press."
    },
    {
      "key": "CIT0009",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-291X(92)90812-Y"
    },
    {
      "key": "CIT0010",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0076-6879(91)00126-H"
    },
    {
      "key": "CIT0011",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/372746a0"
    },
    {
      "key": "CIT0012",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0167-4889(92)90136-Y"
    },
    {
      "key": "CIT0013",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0065-230X(08)60821-0"
    },
    {
      "key": "CIT0014",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.88.4.1095"
    },
    {
      "key": "CIT0015",
      "first-page": "2229",
      "volume": "6",
      "author": "Keegan K.",
      "year": "1991",
      "journal-title": "Oncogene"
    },
    {
      "key": "CIT0016",
      "doi-asserted-by": "publisher",
      "DOI": "10.1182/blood.V85.3.790.bloodjournal853790"
    },
    {
      "key": "CIT0017",
      "doi-asserted-by": "crossref",
      "first-page": "508",
      "DOI": "10.1002/ajmg.1320330420",
      "volume": "33",
      "author": "MacDonald I. M.",
      "year": "1989",
      "journal-title": "Am. J. Med. Genet."
    },
    {
      "key": "CIT0018",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.16.3.977"
    },
    {
      "key": "CIT0019",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/358681a0"
    },
    {
      "key": "CIT0020",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0168-9525(00)89088-5"
    },
    {
      "key": "CIT0021",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.92.23.10560"
    },
    {
      "key": "CIT0022",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.44.26037"
    },
    {
      "key": "CIT0023",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jmg.23.4.328"
    },
    {
      "key": "CIT0024",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/dbio.1993.1040"
    },
    {
      "key": "CIT0025",
      "first-page": "1",
      "volume": "10",
      "author": "Rimoin D. L.",
      "year": "1974",
      "journal-title": "Birth Defects Original Article Series"
    },
    {
      "key": "CIT0026",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/371252a0"
    },
    {
      "key": "CIT0027",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/ng0595-11"
    },
    {
      "key": "CIT0028",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7824936"
    },
    {
      "key": "CIT0029",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1136/jmg.10.3.243",
      "volume": "10",
      "author": "Shah K.",
      "year": "1973",
      "journal-title": "J. Med. Genet."
    },
    {
      "key": "CIT0030",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(94)90302-6"
    },
    {
      "key": "CIT0031",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/4.11.2175"
    },
    {
      "key": "CIT0032",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/ng0395-321"
    },
    {
      "key": "CIT0033",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00384.x"
    },
    {
      "key": "CIT0034",
      "doi-asserted-by": "crossref",
      "first-page": "549",
      "DOI": "10.1083/jcb.123.3.549",
      "volume": "123",
      "author": "Xu Y. F.",
      "year": "1993",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "CIT0035",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(17)35272-9"
    }
  ],
  "container-title": "Molecular and Cellular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/MCB.16.8.4081",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://www.tandfonline.com/doi/pdf/10.1128/MCB.16.8.4081",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        3,
        29
      ]
    ],
    "date-time": "2023-03-29T18:15:29Z",
    "timestamp": 1680113729000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.tandfonline.com/doi/full/10.1128/MCB.16.8.4081"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        8,
        1
      ]
    ]
  },
  "references-count": 35,
  "journal-issue": {
    "issue": "8",
    "published-print": {
      "date-parts": [
        [
          1996,
          8,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1128/MCB.16.8.4081"
  ],
  "URL": "http://dx.doi.org/10.1128/MCB.16.8.4081",
  "relation": {},
  "ISSN": [
    "1098-5549"
  ],
  "subject": [],
  "container-title-short": "Molecular and Cellular Biology",
  "published": {
    "date-parts": [
      [
        1996,
        8,
        1
      ]
    ]
  },
  "assertion": [
    {
      "value": "1996-08-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}