DOI: 10.1128/mcb.14.9.5777. Unusual chromatin in human telomeres.

10.1128/mcb.14.9.5777

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

We report that human telomeres have an unusual chromatin structure characterized by diffuse micrococcal nuclease patterns. The altered chromatin manifested itself only in human telomeres that are relatively short (2 to 7 kb). In contrast, human and mouse telomeres with telomeric repeat arrays of 14 to 150 kb displayed a more canonical chromatin structure with extensive arrays of tightly packed nucleosomes. All telomeric nucleosomes showed a shorter repeat size than bulk nucleosomes, and telomeric mononucleosomal particles were found to be hypersensitive to micrococcal nuclease. However, telomeric nucleosomes were similar to bulk nucleosomes in the rate at which they sedimented through sucrose gradients. We speculate that mammalian telomeres have a bipartite structure with unusual chromatin near the telomere terminus and a more canonical nucleosomal organization in the proximal part of the telomere.

Bibliography

Tommerup, H., Dousmanis, A., & de Lange, T. (1994). Unusual chromatin in human telomeres. Molecular and Cellular Biology, 14(9), 5777â5785.

Authors 3

H Tommerup (first)
A Dousmanis (additional)
T de Lange (additional)

References 0 Referenced 126

None

Dates

Type	When
Created	13 years, 7 months ago (Jan. 24, 2012, 6:22 a.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 9:10 a.m.)
Indexed	4 months, 2 weeks ago (April 11, 2025, 6:50 a.m.)
Issued	30 years, 11 months ago (Sept. 1, 1994)
Published	30 years, 11 months ago (Sept. 1, 1994)
Published Online	30 years, 11 months ago (Sept. 1, 1994)
Published Print	30 years, 11 months ago (Sept. 1, 1994)

Funders 0

None

BibTeX

@article{Tommerup_1994, title={Unusual chromatin in human telomeres.}, volume={14}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.14.9.5777}, DOI={10.1128/mcb.14.9.5777}, number={9}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Tommerup, H and Dousmanis, A and de Lange, T}, year={1994}, month=sep, pages={5777–5785} }

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