DOI: 10.1128/mcb.13.9.5659. Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes.

Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes.

10.1128/mcb.13.9.5659

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

In the yeast Saccharomyces cerevisiae, the Cdc28 protein kinase controls commitment to cell division at Start, but no biologically relevant G1-phase substrates have been identified. We have studied the kinase complexes formed between Cdc28 and each of the G1 cyclins Cln1, Cln2, and Cln3. Each complex has a specific array of coprecipitated in vitro substrates. We identify one of these as Far1, a protein required for pheromone-induced arrest at Start. Treatment with alpha-factor induces a preferential association and/or phosphorylation of Far1 by the Cln1, Cln2, and Cln3 kinase complexes. This induced interaction depends upon the Fus3 protein kinase, a mitogen-activated protein kinase homolog that functions near the bottom of the alpha-factor signal transduction pathway. Thus, we trace a path through which a mitogen-activated protein kinase regulates a Cdc2 kinase.

Bibliography

Tyers, M., & Futcher, B. (1993). Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes. Molecular and Cellular Biology, 13(9), 5659â5669.

Authors 2

M Tyers (first)
B Futcher (additional)

References 0 Referenced 76

None

Dates

Type	When
Created	9 years, 10 months ago (Oct. 5, 2015, 8:36 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 9:09 a.m.)
Indexed	1 year, 1 month ago (July 10, 2024, 11:21 a.m.)
Issued	31 years, 11 months ago (Sept. 1, 1993)
Published	31 years, 11 months ago (Sept. 1, 1993)
Published Online	31 years, 11 months ago (Sept. 1, 1993)
Published Print	31 years, 11 months ago (Sept. 1, 1993)

Funders 0

None

BibTeX

@article{Tyers_1993, title={Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes.}, volume={13}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.13.9.5659}, DOI={10.1128/mcb.13.9.5659}, number={9}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Tyers, M and Futcher, B}, year={1993}, month=sep, pages={5659–5669} }

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