DOI: 10.1128/mcb.13.1.57. MCM1 binds to a transcriptional control element in Ty1.

MCM1 binds to a transcriptional control element in Ty1.

10.1128/mcb.13.1.57

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

Some Ty1 transposable-element insertion mutations of Saccharomyces cerevisiae activate adjacent-gene expression. These Ty1-activated genes are regulated similarly to certain mating genes. This report shows that the MCM1 protein, which binds to several mating genes, also binds to a transcriptional regulatory sequence in Ty1. The binding of MCM1 to Ty1 correlates with the ability of its binding site to function as a component of the Ty1 transcriptional activator. This correlation supports the idea that MCM1 is important for Ty1-activated gene expression. At mating-gene promoters, MCM1 binds with coactivators or repressors such as STE12, alpha 1, or alpha 2. In contrast, MCM1 binds without these associated DNA-binding proteins at its site in Ty1. This finding suggests that its role in Ty1-mediated transcription is different from that at mating genes.

Bibliography

Errede, B. (1993). MCM1 binds to a transcriptional control element in Ty1. Molecular and Cellular Biology, 13(1), 57â62.

Authors 1

B Errede (first)

References 0 Referenced 17

None

Dates

Type	When
Created	9 years, 10 months ago (Oct. 5, 2015, 8:32 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 9:06 a.m.)
Indexed	1 year, 9 months ago (Oct. 29, 2023, 8 a.m.)
Issued	32 years, 7 months ago (Jan. 1, 1993)
Published	32 years, 7 months ago (Jan. 1, 1993)
Published Online	32 years, 7 months ago (Jan. 1, 1993)
Published Print	32 years, 7 months ago (Jan. 1, 1993)

Funders 0

None

BibTeX

@article{Errede_1993, title={MCM1 binds to a transcriptional control element in Ty1.}, volume={13}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.13.1.57}, DOI={10.1128/mcb.13.1.57}, number={1}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Errede, B}, year={1993}, month=jan, pages={57–62} }

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