DOI: 10.1128/mcb.12.6.2749. Instability of simple sequence DNA in Saccharomyces cerevisiae.

Instability of simple sequence DNA in Saccharomyces cerevisiae.

10.1128/mcb.12.6.2749

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

All eukaryotic genomes thus far examined contain simple sequence repeats. A particularly common simple sequence in many organisms (including humans) consists of tracts of alternating GT residues on one strand. Allelic poly(GT) tracts are often of different lengths in different individuals, indicating that they are likely to be unstable. We examined the instability of poly(GT) and poly(G) tracts in the yeast Saccharomyces cerevisiae. We found that these tracts were dramatically unstable, altering length at a minimal rate of 10(-4) events per division. Most of the changes involved one or two repeat unit additions or deletions, although one alteration involved an interaction with the yeast telomeres.

Bibliography

Henderson, S. T., & Petes, T. D. (1992). Instability of simple sequence DNA in Saccharomyces cerevisiae. Molecular and Cellular Biology, 12(6), 2749â2757.

Authors 2

S T Henderson (first)
T D Petes (additional)

References 0 Referenced 100

None

Dates

Type	When
Created	9 years, 11 months ago (Oct. 5, 2015, 8:30 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 9:04 a.m.)
Indexed	1 year, 1 month ago (July 11, 2024, 6:32 p.m.)
Issued	33 years, 3 months ago (June 1, 1992)
Published	33 years, 3 months ago (June 1, 1992)
Published Online	33 years, 3 months ago (June 1, 1992)
Published Print	33 years, 3 months ago (June 1, 1992)

Funders 0

None

BibTeX

@article{Henderson_1992, title={Instability of simple sequence DNA in Saccharomyces cerevisiae.}, volume={12}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.12.6.2749}, DOI={10.1128/mcb.12.6.2749}, number={6}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Henderson, S T and Petes, T D}, year={1992}, month=jun, pages={2749–2757} }

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