DOI: 10.1128/mcb.11.9.4679. Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.

10.1128/mcb.11.9.4679

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

The major positive regulatory activity of the human alpha-globin gene complex has been localized to an element associated with a strong erythroid-specific DNase I hypersensitive site (HS -40) located 40 kb upstream of the zeta 2-globin mRNA cap site. Footprint and gel shift analyses of the element have demonstrated the presence of four binding sites for the nuclear factor GATA-1 and two sites corresponding to the AP-1 consensus binding sequence. This region resembles one of the major elements of the beta-globin locus control region in its constitution and characteristics; this together with evidence from expression studies suggests that HS -40 is a primary element controlling alpha-globin gene expression.

Bibliography

Jarman, A. P., Wood, W. G., Sharpe, J. A., Gourdon, G., Ayyub, H., & Higgs, D. R. (1991). Characterization of the major regulatory element upstream of the human alpha-globin gene cluster. Molecular and Cellular Biology, 11(9), 4679â4689.

Authors 6

A P Jarman (first)
W G Wood (additional)
J A Sharpe (additional)
G Gourdon (additional)
H Ayyub (additional)
D R Higgs (additional)

References 0 Referenced 99

None

Dates

Type	When
Created	9 years, 10 months ago (Oct. 5, 2015, 8:26 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 9:04 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 4, 2024, 1:05 p.m.)
Issued	33 years, 11 months ago (Sept. 1, 1991)
Published	33 years, 11 months ago (Sept. 1, 1991)
Published Online	33 years, 11 months ago (Sept. 1, 1991)
Published Print	33 years, 11 months ago (Sept. 1, 1991)

Funders 0

None

BibTeX

@article{Jarman_1991, title={Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.}, volume={11}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.11.9.4679}, DOI={10.1128/mcb.11.9.4679}, number={9}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Jarman, A P and Wood, W G and Sharpe, J A and Gourdon, G and Ayyub, H and Higgs, D R}, year={1991}, month=sep, pages={4679–4689} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        9,
        4
      ]
    ],
    "date-time": "2024-09-04T17:05:37Z",
    "timestamp": 1725469537429
  },
  "reference-count": 0,
  "publisher": "Informa UK Limited",
  "issue": "9",
  "content-domain": {
    "domain": [
      "asm.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1991,
        9
      ]
    ]
  },
  "abstract": "<jats:p>The major positive regulatory activity of the human alpha-globin gene complex has been localized to an element associated with a strong erythroid-specific DNase I hypersensitive site (HS -40) located 40 kb upstream of the zeta 2-globin mRNA cap site. Footprint and gel shift analyses of the element have demonstrated the presence of four binding sites for the nuclear factor GATA-1 and two sites corresponding to the AP-1 consensus binding sequence. This region resembles one of the major elements of the beta-globin locus control region in its constitution and characteristics; this together with evidence from expression studies suggests that HS -40 is a primary element controlling alpha-globin gene expression.</jats:p>",
  "DOI": "10.1128/mcb.11.9.4679",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2015,
        10,
        6
      ]
    ],
    "date-time": "2015-10-06T00:26:58Z",
    "timestamp": 1444091218000
  },
  "page": "4679-4689",
  "update-policy": "http://dx.doi.org/10.1128/asmj-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 99,
  "title": "Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.",
  "prefix": "10.1080",
  "volume": "11",
  "author": [
    {
      "given": "A P",
      "family": "Jarman",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "W G",
      "family": "Wood",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J A",
      "family": "Sharpe",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "G",
      "family": "Gourdon",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "H",
      "family": "Ayyub",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "D R",
      "family": "Higgs",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "301",
  "published-online": {
    "date-parts": [
      [
        1991,
        9,
        1
      ]
    ]
  },
  "container-title": "Molecular and Cellular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1128/MCB.11.9.4679",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        12,
        15
      ]
    ],
    "date-time": "2022-12-15T14:04:12Z",
    "timestamp": 1671113052000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://mcb.asm.org/lookup/doi/10.1128/MCB.11.9.4679"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1991,
        9
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "9",
    "published-online": {
      "date-parts": [
        [
          1991,
          9,
          1
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          1991,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1128/MCB.11.9.4679"
  ],
  "URL": "http://dx.doi.org/10.1128/MCB.11.9.4679",
  "relation": {},
  "ISSN": [
    "0270-7306",
    "1098-5549"
  ],
  "subject": [],
  "container-title-short": "Mol. Cell. Biol.",
  "published": {
    "date-parts": [
      [
        1991,
        9
      ]
    ]
  }
}