DOI: 10.1128/mcb.11.2.688. Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.

Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.

10.1128/mcb.11.2.688

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

A fragment of the mouse mammary tumor virus (MMTV) promoter was reconstituted from pure histones into a dinucleosome with uniquely positioned octamer cores. Core boundaries for the in vitro-assembled dinucleosome corresponded to the observed in vivo phasing pattern for long terminal repeat nucleosomes A and B. Nuclear factor 1 (NF1), a constituent of the MMTV transcription initiation complex, was excluded from the assembled dinucleosome, whereas the glucocorticoid receptor was able to bind. During transcription of MMTV in vivo, displacement of nucleosome B was necessary to permit assembly of the initiation complex. These results indicate that the nucleoprotein structure of the promoter can provide differential access to sequence-specific DNA-binding proteins and that active chromatin remodeling can occur during transcription activation.

Bibliography

Archer, T. K., Cordingley, M. G., Wolford, R. G., & Hager, G. L. (1991). Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter. Molecular and Cellular Biology, 11(2), 688â698.

Authors 4

T K Archer (first)
M G Cordingley (additional)
R G Wolford (additional)
G L Hager (additional)

References 0 Referenced 180

None

Dates

Type	When
Created	9 years, 10 months ago (Oct. 5, 2015, 8:24 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 8:59 a.m.)
Indexed	1 month ago (July 27, 2025, 3:16 a.m.)
Issued	34 years, 6 months ago (Feb. 1, 1991)
Published	34 years, 6 months ago (Feb. 1, 1991)
Published Online	34 years, 6 months ago (Feb. 1, 1991)
Published Print	34 years, 6 months ago (Feb. 1, 1991)

Funders 0

None

BibTeX

@article{Archer_1991, title={Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.}, volume={11}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.11.2.688}, DOI={10.1128/mcb.11.2.688}, number={2}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Archer, T K and Cordingley, M G and Wolford, R G and Hager, G L}, year={1991}, month=feb, pages={688–698} }

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