DOI: 10.1128/mcb.11.1.573. Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor.

Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor.

10.1128/mcb.11.1.573

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

Three forms of basic fibroblast growth factor (bFGF), initiated at an AUG (18 kDa) and two CUG (21 and 22.5 kDa) start codons, were produced following transfection of COS cells with human hepatoma bFGF cDNA. The subcellular localization of the different forms was investigated directly or by using chimeric genes constructed by fusion of the bFGF and chloramphenicol acetyltransferase open reading frames. The AUG-initiated proteins were cytoplasmic, while the CUG-initiated forms were nuclear. The signal sequence responsible for the nuclear localization of bFGF is contained within 37 amino acid residues between the second CUG and the AUG start codons. Alternative initiation of translation regulates the subcellular localization of bFGF and thus could modulate its role in cell growth and differentiation control.

Bibliography

Bugler, B., Amalric, F., & Prats, H. (1991). Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor. Molecular and Cellular Biology, 11(1), 573â577.

Authors 3

B Bugler (first)
F Amalric (additional)
H Prats (additional)

References 0 Referenced 194

None

Dates

Type	When
Created	9 years, 10 months ago (Oct. 5, 2015, 8:23 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 9:03 a.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 9:16 p.m.)
Issued	34 years, 7 months ago (Jan. 1, 1991)
Published	34 years, 7 months ago (Jan. 1, 1991)
Published Online	34 years, 7 months ago (Jan. 1, 1991)
Published Print	34 years, 7 months ago (Jan. 1, 1991)

Funders 0

None

BibTeX

@article{Bugler_1991, title={Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor.}, volume={11}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.11.1.573}, DOI={10.1128/mcb.11.1.573}, number={1}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Bugler, B and Amalric, F and Prats, H}, year={1991}, month=jan, pages={573–577} }

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