DOI: 10.1128/mcb.10.5.1969. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

10.1128/mcb.10.5.1969

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

We have isolated the gene for a novel growth regulator, amphiregulin (AR), that is evolutionarily related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AR is a bifunctional growth modulator: it interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. The 84-amino-acid mature protein is embedded within a 252-amino-acid transmembrane precursor, an organization similar to that of the TGF-alpha precursor. Human placenta and ovaries were found to express significant amounts of the 1.4-kilobase AR transcript, implicating AR in the regulation of normal cell growth. In addition, the AR gene was localized to chromosomal region 4q13-4q21, a common breakpoint for acute lymphoblastic leukemia.

Bibliography

Plowman, G. D., Green, J. M., McDonald, V. L., Neubauer, M. G., Disteche, C. M., Todaro, G. J., & Shoyab, M. (1990). The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Molecular and Cellular Biology, 10(5), 1969â1981.

Authors 7

G D Plowman (first)
J M Green (additional)
V L McDonald (additional)
M G Neubauer (additional)
C M Disteche (additional)
G J Todaro (additional)
M Shoyab (additional)

References 0 Referenced 216

None

Dates

Type	When
Created	9 years, 10 months ago (Oct. 1, 2015, 5:56 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 9:02 a.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 12:48 a.m.)
Issued	35 years, 4 months ago (May 1, 1990)
Published	35 years, 4 months ago (May 1, 1990)
Published Online	35 years, 4 months ago (May 1, 1990)
Published Print	35 years, 4 months ago (May 1, 1990)

Funders 0

None

BibTeX

@article{Plowman_1990, title={The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.}, volume={10}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.10.5.1969}, DOI={10.1128/mcb.10.5.1969}, number={5}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Plowman, G D and Green, J M and McDonald, V L and Neubauer, M G and Disteche, C M and Todaro, G J and Shoyab, M}, year={1990}, month=may, pages={1969–1981} }

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