DOI: 10.1128/mcb.10.4.1492. Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

10.1128/mcb.10.4.1492

Crossref journal-article

Informa UK Limited

Molecular and Cellular Biology (301)

Abstract

The multifunctional actions of transforming growth factor beta 1 (TGF-beta 1) indicate that it has a pivotal control function in many physiological and pathological processes. An important property of TGF-beta 1 is its ability to activate its own mRNA expression and thereby increase its own secretion. Two distinct regions of the promoter of the TGF-beta 1 gene are responsive to autoregulation: one 5' to the upstream transcriptional start site and another located between the two major start sites. In both promoter regions, autoinduction is mediated by binding of the AP-1 (Jun-Fos) complex. An important contribution to this positive regulation is the autoactivation of c-jun transcription by AP-1. Cotransfection of antisense c-jun or antisense c-fos expression vectors prevents TGF-beta 1 autoinduction. These results demonstrate that both components of the AP-1 complex are required for TGF-beta 1 autoinduction. Induction of jun expression by TGF-beta 1, as well as jun autoinduction, may amplify the action of TGF-beta 1 during normal development and oncogenesis.

Bibliography

Kim, S. J., Angel, P., Lafyatis, R., Hattori, K., Kim, K. Y., Sporn, M. B., Karin, M., & Roberts, A. B. (1990). Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Molecular and Cellular Biology, 10(4), 1492â1497.

Authors 8

S J Kim (first)
P Angel (additional)
R Lafyatis (additional)
K Hattori (additional)
K Y Kim (additional)
M B Sporn (additional)
M Karin (additional)
A B Roberts (additional)

References 0 Referenced 358

None

Dates

Type	When
Created	9 years, 10 months ago (Oct. 1, 2015, 5:55 p.m.)
Deposited	2 years, 8 months ago (Dec. 15, 2022, 9:01 a.m.)
Indexed	3 weeks, 2 days ago (Aug. 7, 2025, 4:38 p.m.)
Issued	35 years, 4 months ago (April 1, 1990)
Published	35 years, 4 months ago (April 1, 1990)
Published Online	35 years, 4 months ago (April 1, 1990)
Published Print	35 years, 4 months ago (April 1, 1990)

Funders 0

None

BibTeX

@article{Kim_1990, title={Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.}, volume={10}, ISSN={1098-5549}, url={http://dx.doi.org/10.1128/mcb.10.4.1492}, DOI={10.1128/mcb.10.4.1492}, number={4}, journal={Molecular and Cellular Biology}, publisher={Informa UK Limited}, author={Kim, S J and Angel, P and Lafyatis, R and Hattori, K and Kim, K Y and Sporn, M B and Karin, M and Roberts, A B}, year={1990}, month=apr, pages={1492–1497} }

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