DOI: 10.1128/jvi.79.5.3200-3205.2005. Entry of Pseudorabies Virus: an Immunogold-Labeling Study

Entry of Pseudorabies Virus: an Immunogold-Labeling Study

10.1128/jvi.79.5.3200-3205.2005

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT Herpesviruses infect cells by fusion of the viral envelope with cellular membranes, primarily the plasma membrane. During this process structural components of the mature virion are lost from the invading nucleocapsid, which then travels along microtubules to the nuclear pore. We examined the penetration process by immunoelectron microscopy and analyzed which of the major tegument proteins remained associated with the incoming capsid. We show that the UL36, UL37, and US3 proteins were present at intracytoplasmic capsids after penetration, whereas the UL11, UL47, UL48, and UL49 tegument proteins were lost. Thus, the three capsid-associated tegument proteins are prime candidates for viral proteins that interact with cellular motor proteins for transport of nucleocapsids to the nucleus.

Bibliography

Granzow, H., Klupp, B. G., & Mettenleiter, T. C. (2005). Entry of Pseudorabies Virus: an Immunogold-Labeling Study. Journal of Virology, 79(5), 3200â3205.

Authors 3

Harald Granzow (first)
Barbara G. Klupp (additional)
Thomas C. Mettenleiter (additional)

References 34 Referenced 130

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Dates

Type	When
Created	20 years, 6 months ago (Feb. 11, 2005, 12:46 p.m.)
Deposited	3 years, 5 months ago (March 5, 2022, 5:03 a.m.)
Indexed	4 months, 1 week ago (April 23, 2025, 3:09 a.m.)
Issued	20 years, 6 months ago (March 1, 2005)
Published	20 years, 6 months ago (March 1, 2005)
Published Print	20 years, 6 months ago (March 1, 2005)

Funders 0

None

BibTeX

@article{Granzow_2005, title={Entry of Pseudorabies Virus: an Immunogold-Labeling Study}, volume={79}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.79.5.3200-3205.2005}, DOI={10.1128/jvi.79.5.3200-3205.2005}, number={5}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Granzow, Harald and Klupp, Barbara G. and Mettenleiter, Thomas C.}, year={2005}, month=mar, pages={3200–3205} }

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