DOI: 10.1128/jvi.79.22.14429-14436.2005. CD46 Is a Cellular Receptor for All Species B Adenoviruses except Types 3 and 7

CD46 Is a Cellular Receptor for All Species B Adenoviruses except Types 3 and 7

10.1128/jvi.79.22.14429-14436.2005

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACTThe 51 human adenovirus serotypes are divided into six species (A to F). Adenovirus serotypes from all species except species B utilize the coxsackie-adenovirus receptor for attachment to host cells in vitro. Species B adenoviruses primarily cause ocular and respiratory tract infections, but certain serotypes are also associated with renal disease. We have previously demonstrated that adenovirus type 11 (species B) uses CD46 (membrane cofactor protein) as a cellular receptor instead of the coxsackie-adenovirus receptor (A. Segerman et al., J. Virol.77:9183-9191, 2003). In the present study, we found that transfection with human CD46 cDNA rendered poorly permissive Chinese hamster ovary cells more permissive to infection by all species B adenovirus serotypes except adenovirus types 3 and 7. Moreover, rabbit antiserum against human CD46 blocked or efficiently inhibited all species B serotypes except adenovirus types 3 and 7 from infecting human A549 cells. We also sequenced the gene encoding the fiber protein of adenovirus type 50 (species B) and compared it with the corresponding amino acid sequences from selected serotypes, including all other serotypes of species B. From the results obtained, we conclude that CD46 is a major cellular receptor on A549 cells for all species B adenoviruses except types 3 and 7.

Bibliography

Marttila, M., Persson, D., Gustafsson, D., Liszewski, M. K., Atkinson, J. P., Wadell, G., & Arnberg, N. (2005). CD46 Is a Cellular Receptor for All Species B Adenoviruses except Types 3 and 7. Journal of Virology, 79(22), 14429â14436.

Authors 7

Marko Marttila (first)
David Persson (additional)
Dan Gustafsson (additional)
M. Kathryn Liszewski (additional)
John P. Atkinson (additional)
Göran Wadell (additional)
Niklas Arnberg (additional)

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Dates

Type	When
Created	19 years, 10 months ago (Oct. 27, 2005, 3:28 p.m.)
Deposited	2 years, 4 months ago (May 4, 2023, 10:40 p.m.)
Indexed	1 month, 2 weeks ago (July 20, 2025, 12:30 a.m.)
Issued	19 years, 9 months ago (Nov. 15, 2005)
Published	19 years, 9 months ago (Nov. 15, 2005)
Published Print	19 years, 9 months ago (Nov. 15, 2005)

Funders 0

None

BibTeX

@article{Marttila_2005, title={CD46 Is a Cellular Receptor for All Species B Adenoviruses except Types 3 and 7}, volume={79}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.79.22.14429-14436.2005}, DOI={10.1128/jvi.79.22.14429-14436.2005}, number={22}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Marttila, Marko and Persson, David and Gustafsson, Dan and Liszewski, M. Kathryn and Atkinson, John P. and Wadell, Göran and Arnberg, Niklas}, year={2005}, month=nov, pages={14429–14436} }

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        "label": "Publication History"
      }
    },
    {
      "value": "2005-11-15",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}