DOI: 10.1128/jvi.79.1.609-614.2005. Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection

Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection

10.1128/jvi.79.1.609-614.2005

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT After the first attachment of virus to the cell surface through a primary receptor, efficient entry of virus requires the presence of a coreceptor. For adeno-associated virus type 2 (AAV2) infection, heparan sulfate proteoglycan is supposed as the primary receptor, and αvβ5 integrin and FGFR1 are reported to act as coreceptors. In this study, we were able to demonstrate that hepatocyte growth factor receptor, c-Met, is also a coreceptor for AAV2 infection. AAV2-mediated transgene analyses revealed that c-Met expression significantly up-regulated transgene expression without increasing AAV2 cell binding. Moreover, a viral overlay assay elucidated the physical interaction between AAV2 and the β subunit of c-Met. These data suggest that c-Met plays the role of coreceptor for AAV2 infection by facilitating AAV2 internalization into the cytoplasm.

Bibliography

Kashiwakura, Y., Tamayose, K., Iwabuchi, K., Hirai, Y., Shimada, T., Matsumoto, K., Nakamura, T., Watanabe, M., Oshimi, K., & Daida, H. (2005). Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection. Journal of Virology, 79(1), 609â614.

Authors 10

Yuji Kashiwakura (first)
Kenji Tamayose (additional)
Kazuhisa Iwabuchi (additional)
Yukihiko Hirai (additional)
Takashi Shimada (additional)
Kunio Matsumoto (additional)
Toshikazu Nakamura (additional)
Masami Watanabe (additional)
Kazuo Oshimi (additional)
Hiroyuki Daida (additional)

References 34 Referenced 190

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Dates

Type	When
Created	20 years, 8 months ago (Dec. 15, 2004, 10:52 p.m.)
Deposited	3 years, 6 months ago (March 5, 2022, 4:36 a.m.)
Indexed	1 week, 3 days ago (Aug. 26, 2025, 3:13 a.m.)
Issued	20 years, 8 months ago (Jan. 1, 2005)
Published	20 years, 8 months ago (Jan. 1, 2005)
Published Print	20 years, 8 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Kashiwakura_2005, title={Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection}, volume={79}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.79.1.609-614.2005}, DOI={10.1128/jvi.79.1.609-614.2005}, number={1}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Kashiwakura, Yuji and Tamayose, Kenji and Iwabuchi, Kazuhisa and Hirai, Yukihiko and Shimada, Takashi and Matsumoto, Kunio and Nakamura, Toshikazu and Watanabe, Masami and Oshimi, Kazuo and Daida, Hiroyuki}, year={2005}, month=jan, pages={609–614} }

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