DOI: 10.1128/jvi.77.7.4431-4434.2003. Treatment of Human Immunodeficiency Virus Type 1 Virions Depleted of Cyclophilin A by Natural Endogenous Reverse Transcription Restores Infectivity

Treatment of Human Immunodeficiency Virus Type 1 Virions Depleted of Cyclophilin A by Natural Endogenous Reverse Transcription Restores Infectivity

10.1128/jvi.77.7.4431-4434.2003

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT We have previously shown that virions with nef deleted can be restored to wild-type infectivity by treatment to induce natural endogenous reverse transcription (NERT). Since Nef and cyclophilin A (CyPA) appear to act in similar ways on postentry events, we determined whether NERT treatment would restore infectivity to virions depleted of CyPA. Our results show that the infectivity of virions depleted of CyPA by treatment with cyclosporine A could be restored by NERT treatment, while mutants in the CyPA binding loop of capsid could only be partially restored. These results suggest that CyPA is involved in some aspect of the uncoating process.

Bibliography

Khan, M., Garcia-Barrio, M., & Powell, M. D. (2003). Treatment of Human Immunodeficiency Virus Type 1 Virions Depleted of Cyclophilin A by Natural Endogenous Reverse Transcription Restores Infectivity. Journal of Virology, 77(7), 4431â4434.

Authors 3

Mahfuz Khan (first)
Minerva Garcia-Barrio (additional)
Michael D. Powell (additional)

References 29 Referenced 7

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Dates

Type	When
Created	22 years, 5 months ago (March 12, 2003, 1:46 p.m.)
Deposited	3 years, 5 months ago (March 5, 2022, 3:20 a.m.)
Indexed	1 year, 3 months ago (May 17, 2024, 3:42 p.m.)
Issued	22 years, 4 months ago (April 1, 2003)
Published	22 years, 4 months ago (April 1, 2003)
Published Print	22 years, 4 months ago (April 1, 2003)

Funders 0

None

BibTeX

@article{Khan_2003, title={Treatment of Human Immunodeficiency Virus Type 1 Virions Depleted of Cyclophilin A by Natural Endogenous Reverse Transcription Restores Infectivity}, volume={77}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.77.7.4431-4434.2003}, DOI={10.1128/jvi.77.7.4431-4434.2003}, number={7}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Khan, Mahfuz and Garcia-Barrio, Minerva and Powell, Michael D.}, year={2003}, month=apr, pages={4431–4434} }

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