DOI: 10.1128/jvi.76.23.12399-12404.2002. Inhibition of Hepatitis Delta Virus RNA Editing by Short Inhibitory RNA-Mediated Knockdown of ADAR1 but Not ADAR2 Expression

Inhibition of Hepatitis Delta Virus RNA Editing by Short Inhibitory RNA-Mediated Knockdown of ADAR1 but Not ADAR2 Expression

10.1128/jvi.76.23.12399-12404.2002

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT Hepatitis delta virus (HDV) requires host RNA editing at the viral RNA amber/W site. Of the two host genes responsible for RNA editing via deamination of adenosines in double-stranded RNAs, short inhibitory RNA-mediated knockdown of host ADAR1 expression but not that of ADAR2 led to decreased HDV amber/W editing and virus production. Despite substantial sequence and structural variation among the amber/W sites of the three HDV genotypes, ADAR1a was primarily responsible for editing all three. We conclude that ADAR1 is primarily responsible for editing HDV RNA at the amber/W site during HDV infection.

Bibliography

Jayan, G. C., & Casey, J. L. (2002). Inhibition of Hepatitis Delta Virus RNA Editing by Short Inhibitory RNA-Mediated Knockdown of ADAR1 but Not ADAR2 Expression. Journal of Virology, 76(23), 12399â12404.

Authors 2

Geetha C. Jayan (first)
John L. Casey (additional)

References 37 Referenced 56

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Dates

Type	When
Created	22 years, 10 months ago (Nov. 1, 2002, 2:04 p.m.)
Deposited	3 years, 5 months ago (March 5, 2022, 2:34 a.m.)
Indexed	1 year ago (Aug. 11, 2024, 3:05 a.m.)
Issued	22 years, 9 months ago (Dec. 1, 2002)
Published	22 years, 9 months ago (Dec. 1, 2002)
Published Print	22 years, 9 months ago (Dec. 1, 2002)

Funders 0

None

BibTeX

@article{Jayan_2002, title={Inhibition of Hepatitis Delta Virus RNA Editing by Short Inhibitory RNA-Mediated Knockdown of ADAR1 but Not ADAR2 Expression}, volume={76}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.76.23.12399-12404.2002}, DOI={10.1128/jvi.76.23.12399-12404.2002}, number={23}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Jayan, Geetha C. and Casey, John L.}, year={2002}, month=dec, pages={12399–12404} }

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