DOI: 10.1128/jvi.75.21.10527-10531.2001. Cyclophilin A-Independent Replication of a Human Immunodeficiency Virus Type 1 Isolate Carrying a Small Portion of the Simian Immunodeficiency Virus SIV <sub>MAC</sub> <i>gag</i> Capsid Region

Cyclophilin A-Independent Replication of a Human Immunodeficiency Virus Type 1 Isolate Carrying a Small Portion of the Simian Immunodeficiency Virus SIV MAC gag Capsid Region

10.1128/jvi.75.21.10527-10531.2001

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT Hybrid viruses between human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus strain mac (SIV MAC ) are invaluable to various fields of HIV-1 research. To date, however, no replication-competent HIV-1 strain containing the gag capsid (CA) region of SIV MAC has been reported. To obtain the viable gag gene chimeric virus in an HIV-1 background, seven HIV-1 strains carrying a part of SIV MAC CA or a small deletion in the CA region were constructed and examined for their biological and biochemical characteristics. While all the recombinants and mutants were found to express Gag and to produce progeny virions on transfection, only one chimeric virus, which has 18 bp of SIV gag CA sequence in place of the region encoding the HIV-1 CA cyclophilin A (CyPA)-binding loop, was infectious for human cell lines. Although this chimeric virus was unable to grow in monkey lymphocytic cells like wild-type (wt) HIV-1 did, it grew much better than wt virus in the presence of cyclosporin A in a human cell line which supports HIV-1 replication in a CyPA-dependent manner. These results indicate that the transfer of a small portion of the SIV MAC CA region to HIV-1 could confer the CyPA-independent replication potential of SIV MAC on the virus.

Bibliography

Fujita, M., Yoshida, A., Miyaura, M., Sakurai, A., Akari, H., Koyama, A. H., & Adachi, A. (2001). Cyclophilin A-Independent Replication of a Human Immunodeficiency Virus Type 1 Isolate Carrying a Small Portion of the Simian Immunodeficiency Virus SIV MAC gag Capsid Region. Journal of Virology, 75(21), 10527â10531.

Authors 7

Mikako Fujita (first)
Akiko Yoshida (additional)
Maki Miyaura (additional)
Akiko Sakurai (additional)
Hirofumi Akari (additional)
A. Hajime Koyama (additional)
Akio Adachi (additional)

References 33 Referenced 13

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:55 a.m.)
Deposited	3 years, 5 months ago (March 5, 2022, 1:24 a.m.)
Indexed	1 year, 4 months ago (April 7, 2024, 12:35 p.m.)
Issued	23 years, 9 months ago (Nov. 1, 2001)
Published	23 years, 9 months ago (Nov. 1, 2001)
Published Print	23 years, 9 months ago (Nov. 1, 2001)

Funders 0

None

BibTeX

@article{Fujita_2001, title={Cyclophilin A-Independent Replication of a Human Immunodeficiency Virus Type 1 Isolate Carrying a Small Portion of the Simian Immunodeficiency Virus SIV MAC gag Capsid Region}, volume={75}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.75.21.10527-10531.2001}, DOI={10.1128/jvi.75.21.10527-10531.2001}, number={21}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Fujita, Mikako and Yoshida, Akiko and Miyaura, Maki and Sakurai, Akiko and Akari, Hirofumi and Koyama, A. Hajime and Adachi, Akio}, year={2001}, month=nov, pages={10527–10531} }

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