DOI: 10.1128/jvi.75.13.6199-6203.2001. Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer [Penn]

Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer

10.1128/jvi.75.13.6199-6203.2001

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT Vectors based on hybrids consisting of adeno-associated virus types 2 (ITRs and Rep) and 5 (Cap) were evaluated for muscle-directed gene transfer (called AAV2/5). Evaluation in immune-competent mice revealed greater transduction efficacy with AAV2/5 than with AAV2 and no cross-neutralization between AAV2/5 and AAV2. Interestingly, we saw no immunologic evidence of previous exposure to AAV5 capsids in a large population of healthy human subjects.

Bibliography

Hildinger, M., Auricchio, A., Gao, G., Wang, L., Chirmule, N., & Wilson, J. M. (2001). Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer. Journal of Virology, 75(13), 6199â6203.

Authors 6

Markus Hildinger (first)
Alberto Auricchio (additional)
Guangping Gao (additional)
Lili Wang (additional)
Narendra Chirmule (additional)
James M. Wilson (additional)

References 18 Referenced 161

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 6:06 a.m.)
Deposited	3 years, 5 months ago (March 5, 2022, 12:55 a.m.)
Indexed	4 months, 3 weeks ago (April 12, 2025, 9:55 p.m.)
Issued	24 years, 2 months ago (July 1, 2001)
Published	24 years, 2 months ago (July 1, 2001)
Published Print	24 years, 2 months ago (July 1, 2001)

Funders 0

None

BibTeX

@article{Hildinger_2001, title={Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer}, volume={75}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.75.13.6199-6203.2001}, DOI={10.1128/jvi.75.13.6199-6203.2001}, number={13}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Hildinger, Markus and Auricchio, Alberto and Gao, Guangping and Wang, Lili and Chirmule, Narendra and Wilson, James M.}, year={2001}, month=jul, pages={6199–6203} }

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