DOI: 10.1128/jvi.74.7.3404-3409.2000. Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon

Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon

10.1128/jvi.74.7.3404-3409.2000

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACTWe have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.

Bibliography

Deonarain, R., AlcamiÌ, A., Alexiou, M., Dallman, M. J., Gewert, D. R., & Porter, A. C. G. (2000). Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon. Journal of Virology, 74(7), 3404â3409.

Authors 6

Raj Deonarain (first)
Antonio Alcamí (additional)
Maria Alexiou (additional)
Margaret J. Dallman (additional)
Dirk R. Gewert (additional)
Andrew C. G. Porter (additional)

References 47 Referenced 147

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10.1128/mcb.10.2.854-858.1990
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Pilon M. Gullberg M. Lundgren E. Transient expression of the CD2 cell surface antigen as a sortable marker to monitor high frequency transfection of human primary B cells.J. Immunol. 146 1991 1047 1051 (10.4049/jimmunol.146.3.1047) / J. Immunol. / Transient expression of the CD2 cell surface antigen as a sortable marker to monitor high frequency transfection of human primary B cells by Pilon M. (1991)
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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 2:06 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 7:49 a.m.)
Indexed	3 weeks, 6 days ago (July 30, 2025, 11:27 a.m.)
Issued	25 years, 4 months ago (April 1, 2000)
Published	25 years, 4 months ago (April 1, 2000)
Published Print	25 years, 4 months ago (April 1, 2000)

Funders 0

None

BibTeX

@article{Deonarain_2000, title={Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon}, volume={74}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.74.7.3404-3409.2000}, DOI={10.1128/jvi.74.7.3404-3409.2000}, number={7}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Deonarain, Raj and Alcamí, Antonio and Alexiou, Maria and Dallman, Margaret J. and Gewert, Dirk R. and Porter, Andrew C. G.}, year={2000}, month=apr, pages={3404–3409} }

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