DOI: 10.1128/jvi.74.10.4634-4644.2000. Influenza Virus Assembly and Lipid Raft Microdomains: a Role for the Cytoplasmic Tails of the Spike Glycoproteins

Influenza Virus Assembly and Lipid Raft Microdomains: a Role for the Cytoplasmic Tails of the Spike Glycoproteins

10.1128/jvi.74.10.4634-4644.2000

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACTInfluenza viruses encoding hemagglutinin (HA) and neuraminidase (NA) glycoproteins with deletions in one or both cytoplasmic tails (HAt− or NAt−) have a reduced association with detergent-insoluble glycolipids (DIGs). Mutations which eliminated various combinations of the three palmitoylation sites in HA exhibited reduced amounts of DIG-associated HA in virus-infected cells. The influenza virus matrix (M1) protein was also found to be associated with DIGs, but this association was decreased in cells infected with HAt− or NAt− virus. Regardless of the amount of DIG-associated protein, the HA and NA glycoproteins were targeted primarily to the apical surface of virus-infected, polarized cells. The uncoupling of DIG association and apical transport was augmented by the observation that the influenza A virus M2protein as well as the influenza C virus HA-esterase-fusion glycoprotein were not associated with DIGs but were apically targeted. The reduced DIG association of HAt− and NAt− is an intrinsic property of the glycoproteins, as similar reductions in DIG association were observed when the proteins were expressed from cDNA. Examination of purified virions indicated reduced amounts of DIG-associated lipids in the envelope of HAt− and NAt− viruses. The data indicate that deletion of both the HA and NA cytoplasmic tails results in reduced DIG association and changes in both virus polypeptide and lipid composition.

Bibliography

Zhang, J., Pekosz, A., & Lamb, R. A. (2000). Influenza Virus Assembly and Lipid Raft Microdomains: a Role for the Cytoplasmic Tails of the Spike Glycoproteins. Journal of Virology, 74(10), 4634â4644.

Authors 3

Jie Zhang (first)
Andrew Pekosz (additional)
Robert A. Lamb (additional)

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Dates

Type	When
Created	23 years ago (July 27, 2002, 1:58 a.m.)
Deposited	1 year, 7 months ago (Jan. 5, 2024, 1:55 p.m.)
Indexed	1 month, 3 weeks ago (June 25, 2025, 1:24 a.m.)
Issued	25 years, 3 months ago (May 15, 2000)
Published	25 years, 3 months ago (May 15, 2000)
Published Print	25 years, 3 months ago (May 15, 2000)

Funders 0

None

BibTeX

@article{Zhang_2000, title={Influenza Virus Assembly and Lipid Raft Microdomains: a Role for the Cytoplasmic Tails of the Spike Glycoproteins}, volume={74}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.74.10.4634-4644.2000}, DOI={10.1128/jvi.74.10.4634-4644.2000}, number={10}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Zhang, Jie and Pekosz, Andrew and Lamb, Robert A.}, year={2000}, month=may, pages={4634–4644} }

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