DOI: 10.1128/jvi.73.2.976-984.1999. Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)

Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)

10.1128/jvi.73.2.976-984.1999

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT In vivo passage of a poorly replicating, nonpathogenic simian-human immunodeficiency virus (SHIV-HXBc2) generated an efficiently replicating virus, KU-1, that caused rapid CD4 + T-lymphocyte depletion and AIDS-like illness in monkeys (S. V. Joag, Z. Li, L. Foresman, E. B. Stephens, L.-J. Zhao, I. Adany, D. M. Pinson, H. M. McClure, and O. Narayan, J. Virol. 70:3189–3197, 1996). The env gene of the KU-1 virus was used to create a molecularly cloned virus, SHIV-HXBc2P 3.2, that differed from a nonpathogenic SHIV-HXBc2 virus in only 12 envelope glycoprotein residues. SHIV-HXBc2P 3.2 replicated efficiently and caused rapid and persistent CD4 + T-lymphocyte depletion in inoculated rhesus macaques. Compared with the envelope glycoproteins of the parental SHIV-HXBc2, the SHIV-HXBc2P 3.2 envelope glycoproteins supported more efficient infection of rhesus monkey peripheral blood mononuclear cells. Both the parental SHIV-HXBc2 and the pathogenic SHIV-HXBc2P 3.2 used CXCR4 but none of the other seven transmembrane segment receptors tested as a second receptor. Compared with the parental virus, viruses with the SHIV-HXBc2P 3.2 envelope glycoproteins were more resistant to neutralization by soluble CD4 and antibodies. Thus, changes in the envelope glycoproteins account for the ability of the passaged virus to deplete CD4 + T lymphocytes rapidly and specify increased replicative capacity and resistance to neutralization.

Bibliography

Cayabyab, M., Karlsson, G. B., Etemad-Moghadam, B. A., Hofmann, W., Steenbeke, T., Halloran, M., Fanton, J. W., Axthelm, M. K., Letvin, N. L., & Sodroski, J. G. (1999). Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2). Journal of Virology, 73(2), 976â984.

Authors 10

Mark Cayabyab (first)
Gunilla B. Karlsson (additional)
Bijan A. Etemad-Moghadam (additional)
Wolfgang Hofmann (additional)
Tavis Steenbeke (additional)
Matilda Halloran (additional)
John W. Fanton (additional)
Michael K. Axthelm (additional)
Norman L. Letvin (additional)
Joseph G. Sodroski (additional)

References 55 Referenced 81

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Dates

Type	When
Created	5 years, 7 months ago (Dec. 31, 2019, 1:22 p.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 10:29 p.m.)
Indexed	4 months, 3 weeks ago (April 8, 2025, 6:09 p.m.)
Issued	26 years, 6 months ago (Feb. 1, 1999)
Published	26 years, 6 months ago (Feb. 1, 1999)
Published Print	26 years, 6 months ago (Feb. 1, 1999)

Funders 0

None

BibTeX

@article{Cayabyab_1999, title={Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)}, volume={73}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.73.2.976-984.1999}, DOI={10.1128/jvi.73.2.976-984.1999}, number={2}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Cayabyab, Mark and Karlsson, Gunilla B. and Etemad-Moghadam, Bijan A. and Hofmann, Wolfgang and Steenbeke, Tavis and Halloran, Matilda and Fanton, John W. and Axthelm, Michael K. and Letvin, Norman L. and Sodroski, Joseph G.}, year={1999}, month=feb, pages={976–984} }

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