DOI: 10.1128/jvi.73.2.1665-1667.1999. Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice

Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice

10.1128/jvi.73.2.1665-1667.1999

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased mortality, elevated virus titers and pathology in liver and spleen, and increased levels of liver enzymes in blood. Cowpox virus on the other hand is more virulent in the presence of perforin than in its absence. An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus.

Bibliography

MuÌllbacher, A., Hla, R. T., Museteanu, C., & Simon, M. M. (1999). Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice. Journal of Virology, 73(2), 1665â1667.

Authors 4

Arno Müllbacher (first)
Ron Tha Hla (additional)
Crisan Museteanu (additional)
Markus M. Simon (additional)

References 17 Referenced 79

10.1084/jem.133.5.1074
Blanden R. V. Progress in immunology. II. Clinical aspects Mechanisms of cell-mediated immunity in viral infection. Brent L. Holborow J. 1974 117 125 North Holland Amsterdam The Netherlands
Blanden R. V. Deak B. D. McDevitt H. O. Immunology of virus diseases 125–138.Strategies in virus-host interactions. Blanden R. V. 1989 Brolga Press Curtin Australia
10.1002/j.1460-2075.1995.tb00097.x
10.1016/1074-7613(94)90063-9
10.1038/369031a0
10.1111/j.1600-065X.1995.tb00686.x
10.1002/eji.1830251209
10.1073/pnas.93.17.9108
10.1073/pnas.93.12.5783
10.1146/annurev.iy.01.040183.001421
10.1016/S0092-8674(00)81874-7
10.1146/annurev.iy.09.040191.001021
10.1084/jem.177.1.195
10.1084/jem.186.10.1781
10.1073/pnas.89.13.6070
10.1084/jem.164.4.1075

Dates

Type	When
Created	5 years, 8 months ago (Dec. 31, 2019, 1:23 p.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 10:29 p.m.)
Indexed	5 months ago (March 30, 2025, 1:23 p.m.)
Issued	26 years, 7 months ago (Feb. 1, 1999)
Published	26 years, 7 months ago (Feb. 1, 1999)
Published Print	26 years, 7 months ago (Feb. 1, 1999)

Funders 0

None

BibTeX

@article{Mu_llbacher_1999, title={Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice}, volume={73}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.73.2.1665-1667.1999}, DOI={10.1128/jvi.73.2.1665-1667.1999}, number={2}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Müllbacher, Arno and Hla, Ron Tha and Museteanu, Crisan and Simon, Markus M.}, year={1999}, month=feb, pages={1665–1667} }

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