DOI: 10.1128/jvi.72.10.8396-8402.1998. Specific and Independent Recognition of U3 and U5 <i>att</i> Sites by Human Immunodeficiency Virus Type 1 Integrase In Vivo

Specific and Independent Recognition of U3 and U5 att Sites by Human Immunodeficiency Virus Type 1 Integrase In Vivo

10.1128/jvi.72.10.8396-8402.1998

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT The retroviral attachment ( att ) sites at viral DNA ends are cis -acting regions essential for proviral integration. To investigate the sequence features of att important for human immunodeficiency virus type 1 (HIV-1) integration in vivo, we generated a series of 25 att mutants of HIV-1 by mutagenesis of the U3, U5, or both boundaries of att . Our results indicated that the terminal 11 or 12 bp of viral DNA are sufficient for specific recognition by HIV-1 integrase (IN) and suggested that IN might recognize each att site independently in vivo.

Bibliography

Masuda, T., Kuroda, M. J., & Harada, S. (1998). Specific and Independent Recognition of U3 and U5 att Sites by Human Immunodeficiency Virus Type 1 Integrase In Vivo. Journal of Virology, 72(10), 8396â8402.

Authors 3

Takao Masuda (first)
Marcelo J. Kuroda (additional)
Shinji Harada (additional)

References 59 Referenced 66

Dates

Type	When
Created	5 years, 7 months ago (Dec. 31, 2019, 1:02 p.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 9:24 p.m.)
Indexed	3 months ago (May 21, 2025, 7:43 a.m.)
Issued	26 years, 10 months ago (Oct. 1, 1998)
Published	26 years, 10 months ago (Oct. 1, 1998)
Published Print	26 years, 10 months ago (Oct. 1, 1998)

Funders 0

None

BibTeX

@article{Masuda_1998, title={Specific and Independent Recognition of U3 and U5 att Sites by Human Immunodeficiency Virus Type 1 Integrase In Vivo}, volume={72}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.72.10.8396-8402.1998}, DOI={10.1128/jvi.72.10.8396-8402.1998}, number={10}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Masuda, Takao and Kuroda, Marcelo J. and Harada, Shinji}, year={1998}, month=oct, pages={8396–8402} }

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