DOI: 10.1128/jvi.72.1.303-308.1998. Cells with High Cyclophilin A Content Support Replication of Human Immunodeficiency Virus Type 1 Gag Mutants with Decreased Ability To Incorporate Cyclophilin A

Cells with High Cyclophilin A Content Support Replication of Human Immunodeficiency Virus Type 1 Gag Mutants with Decreased Ability To Incorporate Cyclophilin A

10.1128/jvi.72.1.303-308.1998

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT Gag polyprotein-mediated incorporation of cellular cyclophilin A (CyPA) into virions is essential for the formation of infectious human immunodeficiency virus type 1 (HIV-1) virions. Either a point mutation in Gag (P222A) or drugs which bind CyPA decrease virion incorporation of CyPA and interfere with HIV-1 replication. We have found that lymphoid cells varied greatly in their CyPA content and that cells with high CyPA content supported the replication of P222A HIV-1 Gag mutants. These experiments demonstrated that a higher cellular CyPA content of some cells was able to compensate for the decreased binding affinity of P222A mutant Gag for CyPA, allowing virus replication to occur.

Bibliography

Ackerson, B., Rey, O., Canon, J., & Krogstad, P. (1998). Cells with High Cyclophilin A Content Support Replication of Human Immunodeficiency Virus Type 1 Gag Mutants with Decreased Ability To Incorporate Cyclophilin A. Journal of Virology, 72(1), 303â308.

Authors 4

Bradley Ackerson (first)
Osvaldo Rey (additional)
Jude Canon (additional)
Paul Krogstad (additional)

References 42 Referenced 39

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Dates

Type	When
Created	5 years, 7 months ago (Dec. 31, 2019, 1 p.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 9:31 p.m.)
Indexed	9 months, 1 week ago (Nov. 19, 2024, 12:53 p.m.)
Issued	27 years, 7 months ago (Jan. 1, 1998)
Published	27 years, 7 months ago (Jan. 1, 1998)
Published Print	27 years, 7 months ago (Jan. 1, 1998)

Funders 0

None

BibTeX

@article{Ackerson_1998, title={Cells with High Cyclophilin A Content Support Replication of Human Immunodeficiency Virus Type 1 Gag Mutants with Decreased Ability To Incorporate Cyclophilin A}, volume={72}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.72.1.303-308.1998}, DOI={10.1128/jvi.72.1.303-308.1998}, number={1}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Ackerson, Bradley and Rey, Osvaldo and Canon, Jude and Krogstad, Paul}, year={1998}, month=jan, pages={303–308} }

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