Abstract
A hepatitis B core antigen (HBcAg) gene bearing the 39-amino-acid-long domain A of hepatitis B surface antigen (HBsAg) within the HBcAg immunodominant loop has been constructed and expressed in Escherichia coli. Chimeric capsids demonstrated HBs but not HBc antigenicity and elicited in mice B-cell and T-cell responses against native HBcAg and HBsAg.
Bibliography
Borisova, G., Arya, B., Dislers, A., Borschukova, O., Tsibinogin, V., Skrastina, D., Eldarov, M. A., Pumpens, P., Skryabin, K. G., & Grens, E. (1993). Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen. Journal of Virology, 67(6), 3696â3701.
Dates
Type | When |
---|---|
Created | 5 years, 7 months ago (Jan. 6, 2020, 11:37 a.m.) |
Deposited | 3 years, 5 months ago (March 4, 2022, 8:37 p.m.) |
Indexed | 4 months, 2 weeks ago (April 8, 2025, 6:09 p.m.) |
Issued | 32 years, 2 months ago (June 1, 1993) |
Published | 32 years, 2 months ago (June 1, 1993) |
Published Print | 32 years, 2 months ago (June 1, 1993) |
@article{Borisova_1993, title={Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen}, volume={67}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.67.6.3696-3701.1993}, DOI={10.1128/jvi.67.6.3696-3701.1993}, number={6}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Borisova, G and Arya, B and Dislers, A and Borschukova, O and Tsibinogin, V and Skrastina, D and Eldarov, M A and Pumpens, P and Skryabin, K G and Grens, E}, year={1993}, month=jun, pages={3696–3701} }