DOI: 10.1128/jvi.67.3.1538-1544.1993. Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans

Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans

10.1128/jvi.67.3.1538-1544.1993

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

Stimulation of human vaccinia virus immune peripheral blood mononuclear cells in vitro from vaccinia virus-immune donors with live vaccinia virus-infected autologous cells generated vaccinia virus-specific cytotoxic T lymphocytes (CTL) capable of lysing vaccinia virus-infected cells. We generated vaccinia virus-specific CD8+ clones and CD4+ CTL lines by limiting dilution from two donors by using peripheral blood mononuclear cells obtained 2 months or 4 years postrevaccination with vaccinia virus. These results demonstrate that vaccinia virus-specific CTL are generated as a result of immunization of humans with vaccinia virus and that both CD8(+)- and CD4(+)-specific T cells are maintained as memory cells.

Bibliography

Demkowicz, W. E., & Ennis, F. A. (1993). Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans. Journal of Virology, 67(3), 1538â1544.

Authors 2

W E Demkowicz (first)
F A Ennis (additional)

References 0 Referenced 44

None

Dates

Type	When
Created	5 years, 8 months ago (Jan. 6, 2020, 11:33 a.m.)
Deposited	3 years, 6 months ago (March 4, 2022, 8:23 p.m.)
Indexed	1 month, 3 weeks ago (July 11, 2025, 6:48 a.m.)
Issued	32 years, 6 months ago (March 1, 1993)
Published	32 years, 6 months ago (March 1, 1993)
Published Print	32 years, 6 months ago (March 1, 1993)

Funders 0

None

BibTeX

@article{Demkowicz_1993, title={Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans}, volume={67}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.67.3.1538-1544.1993}, DOI={10.1128/jvi.67.3.1538-1544.1993}, number={3}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Demkowicz, W E and Ennis, F A}, year={1993}, month=mar, pages={1538–1544} }

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