DOI: 10.1128/jvi.37.1.226-238.1981. Regulatory and coding potential of the mouse mammary tumor virus long terminal redundancy

Regulatory and coding potential of the mouse mammary tumor virus long terminal redundancy

10.1128/jvi.37.1.226-238.1981

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

Molecular clones containing the 3' half of newly integrated mouse mammary tumor virus (MMTV) DNA with adjacent mouse cellular sequences were characterized. In addition, we cloned the long terminal redundancy joint from the unintegrated circular form of MMTV DNA. The entire nucleotide sequence of the integrated and part of the unintegrated terminal redundancy was determined; this allowed us to delineate the boundaries of the MMTV long terminal redundancy, which comprises 1,327 base pairs. The position of possible RNA polymerase II initiation and termination signals corresponded closely to the expected regions of viral RNA initiation and termination specified by current models. The MMTV long terminal redundancy also contained a large open reading frame with sufficient information for a protein of 198 amino acids. Initial comparison of flanking 3' cellular sequences from three independent integrated clones suggested there was no host sequence specificity in the MMTV integration event. However, specificity of integration with respect to viral sequences was precise.

Bibliography

Donehower, L. A., Huang, A. L., & Hager, G. L. (1981). Regulatory and coding potential of the mouse mammary tumor virus long terminal redundancy. Journal of Virology, 37(1), 226â238.

Authors 3

L A Donehower (first)
A L Huang (additional)
G L Hager (additional)

References 0 Referenced 175

None

Dates

Type	When
Created	5 years, 7 months ago (Jan. 5, 2020, 7:55 p.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 5:36 p.m.)
Indexed	3 hours, 9 minutes ago (Sept. 4, 2025, 9:14 a.m.)
Issued	44 years, 8 months ago (Jan. 1, 1981)
Published	44 years, 8 months ago (Jan. 1, 1981)
Published Print	44 years, 8 months ago (Jan. 1, 1981)

Funders 0

None

BibTeX

@article{Donehower_1981, title={Regulatory and coding potential of the mouse mammary tumor virus long terminal redundancy}, volume={37}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.37.1.226-238.1981}, DOI={10.1128/jvi.37.1.226-238.1981}, number={1}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Donehower, L A and Huang, A L and Hager, G L}, year={1981}, month=jan, pages={226–238} }

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