Abstract
The simian virus 40 (SV40) DNA segment in the nondefective adenovirus 2-SV40 hybrid, Ad2 + ND 4 , is colinear with the segment between 0.11 and 0.59 SV40 fractional length from the site at which the R 1 restriction endonuclease cleaves SV40 DNA. This specifies the region of the SV40 DNA molecule which induces the early SV40 antigens: U antigen, tumor specific transplantation antigen, and T antigen. A variant of Ad2 + ND 4 , called Ad2 + ND 4del , was found which has a deletion of the DNA segment between 0.50 and 0.57 SV40 fractional length from the R 1 endonuclease cleavage point.
Dates
Type | When |
---|---|
Created | 5 years, 7 months ago (Jan. 5, 2020, 7:16 p.m.) |
Deposited | 3 years, 5 months ago (March 5, 2022, 11:02 a.m.) |
Indexed | 1 year, 9 months ago (Nov. 23, 2023, 2:10 a.m.) |
Issued | 52 years ago (Sept. 1, 1973) |
Published | 52 years ago (Sept. 1, 1973) |
Published Print | 52 years ago (Sept. 1, 1973) |
@article{Morrow_1973, title={Mapping of Simian Virus 40 Early Functions on the Viral Chromosome}, volume={12}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.12.3.653-658.1973}, DOI={10.1128/jvi.12.3.653-658.1973}, number={3}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Morrow, John F. and Berg, Paul and Kelly, Thomas J. and Lewis, Andrew M.}, year={1973}, month=sep, pages={653–658} }