DOI: 10.1128/jvi.02445-07. Primer Binding Site-Dependent Restriction of Murine Leukemia Virus Requires HP1 Binding by TRIM28

Primer Binding Site-Dependent Restriction of Murine Leukemia Virus Requires HP1 Binding by TRIM28

10.1128/jvi.02445-07

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT TRIM28 is a transcriptional corepressor which is required for primer binding site (PBS)-dependent restriction of murine leukemia virus (MLV) replication in embryonic stem and embryonic carcinoma (EC) cells. PBS-dependent restriction of MLV leads to transcriptional silencing of the integrated provirus and has been shown to correlate with TRIM28-mediated recruitment of HP1 to the silenced loci. Here we show, using a cell line with a point mutation in the HP1 binding domain of TRIM28, that interaction with HP1 is absolutely required for the PBS-dependent restriction of MLV in the F9 EC cell line.

Bibliography

Wolf, D., Cammas, F., Losson, R., & Goff, S. P. (2008). Primer Binding Site-Dependent Restriction of Murine Leukemia Virus Requires HP1 Binding by TRIM28. Journal of Virology, 82(9), 4675â4679.

Authors 4

Daniel Wolf (first)
Florence Cammas (additional)
Régine Losson (additional)
Stephen P. Goff (additional)

References 20 Referenced 63

Dates

Type	When
Created	17 years, 6 months ago (Feb. 20, 2008, 8:45 p.m.)
Deposited	3 years, 5 months ago (March 5, 2022, 7:25 a.m.)
Indexed	3 months ago (May 31, 2025, 10:22 a.m.)
Issued	17 years, 4 months ago (May 1, 2008)
Published	17 years, 4 months ago (May 1, 2008)
Published Print	17 years, 4 months ago (May 1, 2008)

Funders 0

None

BibTeX

@article{Wolf_2008, title={Primer Binding Site-Dependent Restriction of Murine Leukemia Virus Requires HP1 Binding by TRIM28}, volume={82}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.02445-07}, DOI={10.1128/jvi.02445-07}, number={9}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Wolf, Daniel and Cammas, Florence and Losson, Régine and Goff, Stephen P.}, year={2008}, month=may, pages={4675–4679} }

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