DOI: 10.1128/jvi.01876-08. Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D

Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D

10.1128/jvi.01876-08

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

ABSTRACT Cyclophilin A (CypA) is an important human immunodeficiency virus type 1 (HIV-1) cofactor in human cells. HIV-1 A92E and G94D capsid escape mutants arise during CypA inhibition and in certain cell lines are dependent on CypA inhibition. Here we show that dependence on CypA inhibition is due to high CypA levels. Restricted HIV-1 is stable, and remarkably, restriction is augmented by arresting cell division. Nuclear entry is not inhibited. We propose that high CypA levels and capsid mutations combine to disturb uncoating, leading to poor infectivity, particularly in arrested cells. Our data suggest a role for CypA in uncoating the core of HIV-1 to facilitate integration.

Bibliography

Ylinen, L. M. J., Schaller, T., Price, A., Fletcher, A. J., Noursadeghi, M., James, L. C., & Towers, G. J. (2009). Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D. Journal of Virology, 83(4), 2044â2047.

Authors 7

Laura M. J. Ylinen (first)
Torsten Schaller (additional)
Amanda Price (additional)
Adam J. Fletcher (additional)
Mahdad Noursadeghi (additional)
Leo C. James (additional)
Greg J. Towers (additional)

References 23 Referenced 51

Dates

Type	When
Created	16 years, 8 months ago (Dec. 10, 2008, 8:34 p.m.)
Deposited	3 years, 5 months ago (March 5, 2022, 7:47 a.m.)
Indexed	1 month, 2 weeks ago (July 2, 2025, 10:19 a.m.)
Issued	16 years, 6 months ago (Feb. 15, 2009)
Published	16 years, 6 months ago (Feb. 15, 2009)
Published Print	16 years, 6 months ago (Feb. 15, 2009)

Funders 0

None

BibTeX

@article{Ylinen_2009, title={Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D}, volume={83}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.01876-08}, DOI={10.1128/jvi.01876-08}, number={4}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Ylinen, Laura M. J. and Schaller, Torsten and Price, Amanda and Fletcher, Adam J. and Noursadeghi, Mahdad and James, Leo C. and Towers, Greg J.}, year={2009}, month=feb, pages={2044–2047} }

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