DOI: 10.1128/jb.98.1.215-221.1969. Naturally Occurring Penicillinase Plasmids in <i>Staphylococcus aureus</i>

Naturally Occurring Penicillinase Plasmids in Staphylococcus aureus

10.1128/jb.98.1.215-221.1969

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

A series of plasmids harbored by naturally occurring penicillin-resistant strains of Staphylococcus aureus were surveyed with a view toward exploring the variability in plasmid-linked marker patterns. Plasmids were transduced from their natural hosts to either of two plasmid-negative laboratory strains by selection for cadmium resistance, and the transductants were tested for all other markers previously found to be plasmid-linked. All of the strains that were able to serve as genetic donors to one of the two stock strains could donate cadmium and lead resistance as linked, plasmid-borne markers. Among the other plasmid markers, a wide variety of patterns was found, including four plasmids that did not carry the penicillinase determinant. Each of the 26 plasmids studied, including the latter 4, was found to belong to one of the two incompatibility sets of penicillinase plasmids previously identified. With the exception of the penicillinase-negative plasmids, which were found in both sets, all the plasmids of incompatibility set I directed the production of penicillinase type A; those belonging to set II directed either type A or type C. Those of set II without exception increased the sensitivity of their host strains to bismuth ion; those of set I carried determinants of bismuth resistance or did not affect the sensitivity of their host to this ion. No other perfect correlations between markers were encountered; in particular, there was no correlation between penicillinase serotype and the excretion of the enzyme. This finding allows the prediction that there is, in addition to all of the markers thus far identified, a plasmid-linked determinant of penicillinase excretion.

Bibliography

Peyru, G., Wexler, L. F., & Novick, R. P. (1969). Naturally Occurring Penicillinase Plasmids in Staphylococcus aureus. Journal of Bacteriology, 98(1), 215â221.

Authors 3

Graciela Peyru (first)
Laura Fooner Wexler (additional)
Richard P. Novick (additional)

References 21 Referenced 63

Asheshov , E. H. 1966 . Chromosomal location of the genetic elements controlling penicillinase production in a strain of Staphylococcus aureus . Nature 210 : 804 - 806 . (10.1038/210804a0) / Nature / Chromosomal location of the genetic elements controlling penicillinase production in a strain of Staphylococcus aureus by Asheshov E. H. (1966)
Asheshov , E. H. , and K. G. H. Dyke . 1968 . Regulation of the synthesis of penicillinase in diploids of Staphylococcus aureus . Biochem. Biophys. Res. Commun. 30 : 213 - 218 . (10.1016/0006-291X(68)90437-3) / Biochem. Biophys. Res. Commun. / Regulation of the synthesis of penicillinase in diploids of Staphylococcus aureus by Asheshov E. H. (1968)
Cohen S. and H. M. Sweeney. 1968. Constitutive penicillinase formation in Staphylococcus aureus owing to a muta-VOL. 98 1969 PENICILLINASE PLASMIDS IN S. AUREUS (10.1128/jb.95.4.1368-1374.1968)
Demerec , M. , E. A. Adelberg , A. J. Clark , and P. E. Hartman . 1966 . A proposal for a uniform nomenclature in bacterial genetics . Genetics 54 : 61 - 76 . (10.1093/genetics/54.1.61) / Genetics / A proposal for a uniform nomenclature in bacterial genetics by Demerec M. (1966)
Dyke , K. G. H. , and M. H. Richmond . 1967 . Occurrence of various types of penicillinase plasmid among 'hospital' staphylococci . J. Clin. Pathol. (London) 20 : 75 - 79 . (10.1136/jcp.20.1.75) / J. Clin. Pathol. (London) / Occurrence of various types of penicillinase plasmid among 'hospital' staphylococci by Dyke K. G. H. (1967)
Jacob , F. , S. Brenner , and F. Cuzin . 1963 . On the regulation of DNA replication in bacteria . Cold Spring Harbor Symp. Quant. Biol. 28 : 329 - 348 . (10.1101/SQB.1963.028.01.048) / Cold Spring Harbor Symp. Quant. Biol. / On the regulation of DNA replication in bacteria by Jacob F. (1963)
Mitsuhashi S. , H. Hashimoto , M. Kono , and M. Morimura . 1965 . Drug resistance of staphylococci. II. Joint elimination and joint transduction of the determinants of penicillinase production and resistance to macrolide antibiotics . J. Bacteriol. 89 : 988 - 992 . (10.1128/JB.89.4.988-992.1965) / J. Bacteriol. / Drug resistance of staphylococci. II. Joint elimination and joint transduction of the determinants of penicillinase production and resistance to macrolide antibiotics by Mitsuhashi S. (1965)
Novick , R. P. 1962 . Staphylococcal penicillinase and the new penicillins . Biochem. J. 83 : 229 - 235 . (10.1042/bj0830229) / Biochem. J. / Staphylococcal penicillinase and the new penicillins by Novick R. P. (1962)
Novick , R. P. 1963 . Analysis by transduction of mutations affecting penicillinase synthesis in S. aureus J . Gen. Microbiol. 33 : 121 - 136 . (10.1099/00221287-33-1-121) / Gen. Microbiol. / Analysis by transduction of mutations affecting penicillinase synthesis in S. aureus J by Novick R. P. (1963)
Novick , R. P. 1967 . Penicillinase plasmids of S. aureus . Federation Proc. 26 : 29 - 38 . / Federation Proc. / Penicillinase plasmids of S. aureus by Novick R. P. (1967)
Novick , R. P. , and M. H. Richmond . 1965 . Nature and interactions of the genetic elements governing penicillinase syn- thesis in Staphylococcus aureus . J. Bacteriol. 90 : 467 - 480 . (10.1128/JB.90.2.467-480.1965) / J. Bacteriol. / Nature and interactions of the genetic elements governing penicillinase syn- thesis in Staphylococcus aureus by Novick R. P. (1965)
Novick , R. P. , and C. Roth . 1968 . Plasmid-linked resistance to inorganic salts in Staphylococcus aureus . J. Bacteriol. 95 : 1335 - 1342 . (10.1128/jb.95.4.1335-1342.1968) / J. Bacteriol. / Plasmid-linked resistance to inorganic salts in Staphylococcus aureus by Novick R. P. (1968)
Perret , C. J. 1954 . Iodometric assay of penicillinase . Nature 174 : 1012 . (10.1038/1741012a0) / Nature / Iodometric assay of penicillinase by Perret C. J. (1954)
Poston , S. M. 1966 . Cellular location of the genes controlling penicillinase production and resistance to streptomycin and tetracycline in a strain of Staphylococcus aureus . Nature 210 : 802 - 804 . (10.1038/210802a0) / Nature / Cellular location of the genes controlling penicillinase production and resistance to streptomycin and tetracycline in a strain of Staphylococcus aureus by Poston S. M. (1966)
Richmond , M. H. 1965 . Dominance of the inducible state in strains of Staphylococcus aureus containing two distinct penicillinase plasmids . J. Bacteriol. 90 : 370 - 374 . (10.1128/JB.90.2.370-374.1965) / J. Bacteriol. / Dominance of the inducible state in strains of Staphylococcus aureus containing two distinct penicillinase plasmids by Richmond M. H. (1965)
Richmond , M. H. 1965 . Penicillinase plasmids in S. aureus. Brit . Med. Bull. 21 : 260 - 263 . (10.1093/oxfordjournals.bmb.a070406) / Med. Bull. / Penicillinase plasmids in S. aureus. Brit by Richmond M. H. (1965)
Richmond , M. H. 1965 . Wild-type variants of exopenicillinnase from Staphylococcus aureus . Biochem. J. 94 : 584 - 593 . (10.1042/bj0940584) / Biochem. J. / Wild-type variants of exopenicillinnase from Staphylococcus aureus by Richmond M. H. (1965)
Richmond M. H. 1968. The plasmids of Staphylococcus aureus and their relation to other extrachromosomal elements in bacteria p. 43-88. In A. H. Rose and J. F. Wilkinson (ed.) Advances in microbial physiology vol. 2. Academic Press Inc. New York. (10.1016/S0065-2911(08)60259-3)
Segalove , M. 1947 . The effect of penicillin on growth and pro- duction by enterotoxic staphylococci . J. Infect. Diseases 81 : 228 - 243 . (10.1093/infdis/81.3.228) / J. Infect. Diseases / The effect of penicillin on growth and pro- duction by enterotoxic staphylococci by Segalove M. (1947)
Sweeney , H. M. , and S. Cohen . 1968 . Wild-type strain of Staphylococcus aureus containing two genetic linkage groups for penicillinase production . J. Bacteriol. 96 : 920 - 924 . (10.1128/jb.96.4.920-924.1968) / J. Bacteriol. / Wild-type strain of Staphylococcus aureus containing two genetic linkage groups for penicillinase production by Sweeney H. M. (1968)
Watanabe , T. , H. Nishida , C. Ogata , T. Arai , and S. Sato . 1964 . Episome-mediated transfer of drug resistance in Enterobacteriaceae. VII. Two types of naturally occurring R factors . J. Bacteriol. 88 : 716 - 726 . (10.1128/JB.88.3.716-726.1964) / J. Bacteriol. / Episome-mediated transfer of drug resistance in Enterobacteriaceae. VII. Two types of naturally occurring R factors by Watanabe T. (1964)

Dates

Type	When
Created	5 years, 7 months ago (Jan. 4, 2020, 9:16 p.m.)
Deposited	4 years, 1 month ago (July 29, 2021, 12:52 p.m.)
Indexed	1 year, 9 months ago (Nov. 20, 2023, 4:45 p.m.)
Issued	56 years, 5 months ago (April 1, 1969)
Published	56 years, 5 months ago (April 1, 1969)
Published Print	56 years, 5 months ago (April 1, 1969)

Funders 0

None

BibTeX

@article{Peyru_1969, title={Naturally Occurring Penicillinase Plasmids in Staphylococcus aureus}, volume={98}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.98.1.215-221.1969}, DOI={10.1128/jb.98.1.215-221.1969}, number={1}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Peyru, Graciela and Wexler, Laura Fooner and Novick, Richard P.}, year={1969}, month=apr, pages={215–221} }

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